PI3K/AKT/mTOR通路及免疫球蛋白参与的肉芽肿性小叶乳腺炎发病机制研究  

Study of PI3K/AKT/mTOR pathway and immunoglobulin in the pathogenesis of granulomatous lobular mastitis

作　　者：赵阳[1] 王西京[2] 张淑群[2] 康华峰[2] 管海涛[2] 靳耀锋[2] 单昌友 刁岩[1] ZHAO Yang;WANG Xijing;ZHANG Shuqun;KANG Huafeng;GUAN Haitao;JIN Yaofeng;SHAN Changyou;DIAO Yan(Department of Oncology,the Second Affiliated Hospital of Xi′an Jiaotong University,Shaanxi Province,Xi′an 710004,China;Department of Pathology,the Second Affiliated Hospital of Xi′an Jiaotong University,Shaanxi Province,Xi′an 710004,China)

机构地区：[1]西安交通大学第二附属医院肿瘤科,陕西西安710004 [2]西安交通大学第二附属医院病理科,陕西西安710004

出　　处：《中国医药导报》2018年第30期8-10,共3页China Medical Herald

基　　金：陕西省重点研发计划项目(2017SF-250)

摘　　要：目的分析PI3K/AKT/mTOR通路及免疫球蛋白参与的肉芽肿性小叶乳腺炎发病机制,为相关治疗提供参考。方法选取2015年6月～2016年6月西安交通大学第二附属医院(以下简称"我院")收治的60例肉芽肿性小叶乳腺炎患者作为观察组,选取我院同期健康体检者30名作为对照组,分析患者PI3K/AKT/mTOR通路蛋白及免疫球蛋白水平变化。结果与对照组比较,观察组PI3K、AKT、m TOR及白细胞介素-2(IL-2)、IL-6、IL-10水平明显升高,IgA、IgM及IgG水平明显降低,且差异均有统计学意义(P <0.05)。结论 PI3K/AKT/mTOR通路及免疫球蛋白与非肉芽肿性小叶乳腺炎发病过程密切相关。Objective To analyze the pathogenesis of granulomatous lobular mastitis involved in PI3K/AKT/mTOR pathway and immunoglobulin,and provide reference for related treatment.Methods Sixty patients with granulomatous lobular mastitis diagnosed and treated from June 2015 to June 2016 in the Second Affiliated Hospital of Xi′an Jiaotong University(“our hospital”for short)were selected as the observation group.Thirty healthy subjects in our hospital were selected as the control group.The patient′s PI3K/AKT/mTOR pathway protein and immunoglobulin levels were analyzed.Results Compared with the control group,the levels of PI3K,AKT,mTOR and interleukin-2(IL-2),IL-6,IL-10 were significantly increased in the observation group,and the levels of immunoglobulin IgA,IgM and IgG were significantly decreased,the differences were statistically significant(P<0.05).Conclusion PI3K/AKT/mTOR pathway proteins and immunoglobulin have a close relationship with the pathogenesis of granulomatous lobular mastitis.

关 键 词：PI3K/AKT/mTOR信号通路 免疫球蛋白 白细胞介素 肉芽肿性小叶乳腺炎 

分 类 号：R655.8[医药卫生—外科学]