用于可寻址生物电子芯片信号源系统的设计及应用  

Design and application of signal source system for addressable bioelectronic chip

作　　者：程洁 徐伟[4] 李生辉[1,3] 叶一霏 马瑶瑶 段佳辉 黄成军[1,2,3] CHENG Jie;XU Wei;LI Shenghui;YE Yifei;MA Yaoyao;DUAN Jiahui;HUANG Chengjun(R&D Center of Healthcare Electronics,Institute of Microelectronics of Chinese Academy of Sciences,Beijing 100029,China;School of Future Technology,University of Chinese Academy of Sciences,Beijing 101400,China;Beijing Key Laboratory of Radio Frequency IC Technology for Next Generation Communications,Institute of Microelectronics of Chinese Academy of Sciences,Beijing 100029,China;Department of Information Technology,Hubei University of Police,Wuhan 430043,China)

机构地区：[1]中国科学院微电子研究所健康电子研发中心,北京100029 [2]中国科学院大学未来技术学院,北京101400 [3]中国科学院微电子研究所新一代通信射频芯片技术北京市重点实验室,北京100029 [4]湖北警官学院信息技术系,湖北武汉430043

出　　处：《现代电子技术》2018年第21期150-155,共6页Modern Electronics Technique

基　　金：国家自然科学基金(61372028);国家自然科学基金(61571437);国家重点研发计划(2016YFC0900201);湖北省中国科学院科技合作专项项目资助~~

摘　　要：直接数字式合成(DDS)是频率合成领域内一种关键的技术,广泛应用在无线电通信领域。随着生物芯片技术的发展,基于介电电泳的生物芯片对信号源的需求越来越强烈。提出基于DDS模块AD9850的介电电泳生物芯片的信号源系统,提供一组频率在1 kHz^30 MHz,幅值在0.5~4 V的同频等幅同反相正弦信号,实际应用于一种可寻址的细胞捕获微流控芯片。测试结果表明,所设计的信号源系统能很好满足介电电泳生物芯片对信号源的需求,将其应用于研发的介电电泳生物芯片上,成功实现了对肿瘤细胞的捕获。The direct digital synthesizer(DDS)as a key technology of frequency synthesis field is widely used in the field of radio communication.In recent years,with the development of biochip technology,the requirement of dielectrophoresis biochip for signal source becomes exigent.A DDS module AD9850 based signal source system of dielectrophoresis biochip is proposed,which can provide a couple of opposite sinusoidal signals with same frequency of 1 kHz^30 MHz and same amplitude of 0.5~4 V,and is applied to an addressable cell capture microfluidic chip.The testing results show that the designed signal source system can meet the requirement of dielectrophoresis biochip for signal source,and is applied to dielectrophoresis biochip to realize the capture of tumour cell successfully.

关 键 词：直接数字式合成 介电电泳 生物芯片 AD9850 信号源 细胞捕获 

分 类 号：TN741-34[电子电信—电路与系统]