一氧化碳中毒迟发性脑病与脑细胞自噬的研究进展  

Research progress on delayed encephalopathy and cerebral autophagy caused by carbon monoxide poisoning

作　　者：张德新[1] 詹洁[1] 王小霞 吕信鹏 邓颖[1] ZHANG De-xin;ZHAN Jie;WANG Xiao-xia;Lv Xin-peng;DENG Ying(Department of Emergency,the Second Hospital of Harbin Medical University,Harbin 150086,Heilongjiang,China)

机构地区：[1]哈尔滨医科大学附属第二医院急诊科,哈尔滨150086

出　　处：《中国临床医学》2018年第5期827-829,共3页Chinese Journal of Clinical Medicine

基　　金：北京协和医学基金会"睿E(睿意)急诊医学研究专项基金"项目(RE2016-014)~~

摘　　要：一氧化碳中毒迟发性脑病(delayed encephalopathy after carbon monoxide poisoning,DEACMP)的发病率较高,对患者及家庭造成极大的痛苦和经济负担,其发病机制仍然不明。一氧化碳中毒时,一氧化碳可通过多种途径启动脑细胞自噬。自噬参与了DEACMP的发病,但自噬在疾病不同阶段的水平及发挥的作用,仍未得出一致的结论。The incidence of delayed encephalopathy after carbon monoxide poisoning(DEACMP)is high,which causes agony and economic burden to patients and their families.The pathogenesis of DEACMP is still unknown.When carbon monoxide poisoning happens,carbon monoxide can activate autophagy of brain cells through many pathways.Autophagy is involved in the onset of DEACMP,but its levels and roles at different stages of the disease have not reached a unanimous conclusion.

关 键 词：一氧化碳中毒 迟发性脑病 脑细胞 自噬 

分 类 号：R595.1[医药卫生—内科学]