十二指肠空肠旁路术与全胃Roux-en-Y吻合术对大鼠水钠平衡的影响  

Effect of Duodenal Jejunal Bypass and Roux-en-Y Reconstruction after Total Gastrectomy on the Balance of Water and Sodium in Rats

作　　者：洪杰 蔡志聪 杨为锦[3] 林楠[3] 吴伟航[3] 林丽 林晨[3] 王瑜[3] Hong Jie;Cai Zhicong;Yang Weijin(Fuzhou General Hospital of Fujian University of Traditional Chinese Medicine,Fujian 350025,China)

机构地区：[1]福建中医药大学福总临床医学院普通外科,福州350025 [2]福建医科大学福总临床医学院,福州350025 [3]解放军福州总医院普通外科,350025

出　　处：《医学研究杂志》2018年第10期75-78,共4页Journal of Medical Research

基　　金：福建省自然科学基金资助项目(2017J01317)

摘　　要：目的探讨十二指肠空肠旁路术(duodenal jejunal bypass,DJB)与全胃Roux-en-Y吻合术(Roux-en-Y reconstruction after total gastrectomy,RYTG)对SD大鼠水钠平衡的影响。方法通过建立SD大鼠十二指肠空肠旁路术(DJB)与全胃Roux-en-Y吻合术(RYTG)及假手术3组手术模型,动态监测3组SD大鼠术前、术后1周、4周、8周体重、24h饮水量、尿量、及尿钠的情况。结果与假手术组比较,SD大鼠接受不同的胃转流术后体重都有一定程度的下降,但RYTG组SD大鼠体重下降的幅度远大于DJB组;同时RYTG组术后24h饮水量、尿量、以及尿钠明显比同时期的DJB组高,而假手术组,无论在体重,还是术后24h饮水量、尿量、尿钠均无明显变化。结论胃转流术后,SD大鼠24h饮水量、尿量、尿钠明显增加,RYTG组较DJB组增加更为显著,这些现象为胃转流术术后体内水钠平衡调节、体重下降,以及血压变化指明了研究方向,具有一定的参考意义。Objective To investigate the effect of Duodenal-Jejunal bypass(DJB)and Roux-en-Y reconstruction after total gastrectomy(RYTG)on the balance of water and sodium in rats.Methods The three surgical models of the Duodenal Jejunal Bypass(DJB)and Roux-en-Y Reconstruction after Total Gastrectomy(RYTG)and sham operation were established by SD rats.Body weight,24h water intake,24h urine volume and 24h urine sodium of the rats were monitored dynamically before operation and 1st week,4th week and 8th week after operation.Results Compared with sham group,the weights of SD rats after different gastric bypass surgery were all decreased to some extent.However,the degree of weight loss in RYTG group were significantly higher than DJB group.Meanwhile,the postoperative 24h water intake,24h urine volume and 24h urine sodium in RYTG group were significantly higher than those in the DJB group at every time point.In the sham operation group,there were no significant changes in body weight,postoperative 24h water intake,24h urine volume,and 24h urinary sodium.Conclusion After gastric bypass surgery,24h water intake,24h urine volume and 24h urine sodium increased significantly in rats,especially in the RYTG group.These phenomena has pointed out the research direction of water and sodium balance regulation,weight loss,and blood pressure changes after gastric bypass surgery,which has a certain reference value.

关 键 词：十二指肠空肠旁路术 胃转流术 尿钠 全胃Roux-en-Y吻合术 

分 类 号：R3[医药卫生—基础医学] R6