慢性心力衰竭患者血清蛋白电泳的特点分析  

Analysis of Serum Protein Electrophoresis in Patients with Chronic Heart Failure

作　　者：李群[1] 熊筱伟 郭晓彬[1] 龚洪涛[1] 陈步星[1] Li qun;Xiong Xiaowei;Guo Xiaobin(Department of Cardiology,Beijing Tiantan Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京天坛医院心内科,100050

出　　处：《医学研究杂志》2018年第10期103-106,共4页Journal of Medical Research

摘　　要：目的分析慢性心力衰竭(chronic heart failure,CHF)患者血清蛋白电泳(serum protein electrophoresis,SPEP)的特点并评价其对CHF患者的预后价值。方法回顾性分析59例CHF患者(研究组)和58例其他疾病患者(对照组)的SPEP差异。结合CHF患者的随访信息分析SPEP与研究组患者心血管事件(再住院和死亡)的相关性,并分析SPEP与其他常规检查指标的相关性,并探索其可能原因。结果同对照组比较,研究组CHF患者β1球蛋白的水平显著升高(P <0. 05)。在7～24个月的随访中,在β1球蛋白水平6%上限的患者比β1球蛋白水平6%下限的患者具有更高的出院后不良事件发生率(P <0. 05)。同时,血清β1球蛋白的水平与血肌酐、尿酸和血钠水平呈显著相关(P <0. 05)。结论 CHF患者具有较高的β1球蛋白水平,并且能很大程度上影响其预后。由于低灌注和血清免疫球蛋白聚集的原因,CHF患者升高的血清β1球蛋白水平与血肌酐、尿酸和血钠水平密切相关,成为肾功能异常的一个风险因素。Objective To analyze the characteristics of serum protein electrophoresis(SPEP)in chronic heart failure(CHF)patient sand evaluate its prognostic value.Methods We retrospectively explored the difference of SPEPs between of 59 CHF patients in study cohort and 58 patients with other disease in control cohort,and analyzed the correlation between cardiovascular events(Hospitalization or deaths)and their SPEP according to the followed data.Finally we analyzed the correlations between the SPEP and other routine biomarker sand explore the potential reason of them.Results Compared with control cohort patients,patients of study cohort appear had significantly higher beta 1-gobulin level(P<0.05).In the study cohort,during the 7 to 24months post-discharge period,patients with beta 1-gobulin higher than 6%had much more adverse event rate(re-hospitalization and deaths)than those with beta 1-gobulin less than 6%(P<0.05).Meanwhile,the correlations between beta 1-gobulin and blood creatinine,uric acid and blood natrium were significant respectively(P<0.05).Conclusion CHF patients had higher beta 1-gobulin which may largely affect their prognosis after hospital discharge.The growing beta 1-gobulin is closely correlated with blood creatinine,uric acid and blood natrium and becomes a risk of kidney dysfunction.

关 键 词：血清蛋白电泳 慢性心力衰竭 预后 β1球蛋白 Γ球蛋白 

分 类 号：R4[医药卫生—临床医学]