GLP-1类似物利拉鲁肽联合门冬胰岛素30对2型糖尿病患者认知功能障碍的影响  

Effect of GLP-1 receptor agonist combined with insulin aspart30 on cognitive impairment of patients with type 2 diabetes mellitus

作　　者：李伟[1] 王梅[1] 董雪 吕梁 付兴根[1] 王德忠[1] Wei Li;Mei Wang;Xue Dong;Liang Lü;Xing-gen Fu;De-zhong Wang(Department of Endocrinology,Tengzhou Central People’s Hospital,Tengzhou,Shandong 277500,China)

机构地区：[1]山东省滕州市中心人民医院内分泌二科,山东滕州277500

出　　处：《中国现代医学杂志》2018年第31期108-112,共5页China Journal of Modern Medicine

摘　　要：目的探究GLP-1类似物利拉鲁肽联合门冬胰岛素30治疗2型糖尿病患者认知功能障碍的临床疗效。方法连续入选2014年9月-2016年1月山东省滕州市中心人民医院内住院的2型糖尿病患者132例,将患者随机分成门冬胰岛素30治疗组(对照组,66例)和利拉鲁肽联合门冬胰岛素30治疗组(实验组,66例),治疗1年后随访结果,比较分析治疗前后两组患者血糖、血脂、体重指数及认知功能的变化情况。结果治疗1年后随访,实验组的血糖、体重指数较对照组改善,认知功能量表MMSE、MoCA、CMS总分均高于对照组(P<0.05)。结论利拉鲁肽联合门冬胰岛素30在控制血糖、降血脂、改善体重指数方面的临床疗效优于单纯的门冬胰岛素30,且有效改善糖尿病患者认知功能。Objective To investigate the effect of glucagon-like peptide-1(GLP-1)receptor agonist Liraglutide combined with insulin aspart 30 on the cognitive impairment of the patients with type 2 diabetes mellitus.Methods A total of 132 consecutive patients with type 2 diabetes mellitus in our hospital between September 2014 and January 2016 were recruited.The patients were randomly divided into two treatment groups:insulin aspart 30 group(control group,66 cases),Liraglutide combined with insulin aspart 30 group(research group,66 cases).The patients were followed up 1 y after treatment.The changes of blood glucose,lipid biochemical indexes,body mass index(BMI)and cognitive function before and after treatment were compared between the two groups.Results The follow-up results showed that glucose and BMI in the research group were improved when compared with the control group,and the total scores of cognitive function scales MMSE,MoCA and CMS were higher than those in the control group(P<0.05).Conclusions Liraglutide combined with insulin aspart 30 has better clinical curative effect in the control of blood glucose,reducing blood lipids and improving BMI than insulin aspart 30 alone,and it can also improve the cognitive function of the patients with diabetes mellitus.

关 键 词：利拉鲁肽 门冬胰岛素30 认知功能障碍 2型糖尿病 

分 类 号：R587.2[医药卫生—内分泌]