绝经后女性2型糖尿病患者的DKK1蛋白表达水平及其临床意义  

Expression level of DKK1 protein in postmenopausal women with type 2 diabetes mellitus

作　　者：徐海洋 周琼 李军[1] 李思源[3] 孙侃[1] 常向云[1] 王晓丽[1] 胡颖 Hai-yang Xu;Qiong Zhou;Jun Li;Si-yuan Li;Kan Sun;Xiang-yun Chang;Xiao-li Wang;Ying Hu(Department of Endocrinology,the First Affiliated Hospital,School of Medicine,Shihezi University,Shihezi,Xinjiang 832000,China;The 29th Regiment Hospital of the Second Xinjiang Devision,Kuerle,Xinjiang 841000,China;School of Medicine,Shihezi University,Shihezi,Xinjiang 832000,China;The Fourth Affiliated Hospital,Xinjiang Medical University,Urumqi,Xinjaing 830000,China)

机构地区：[1]石河子大学医学院第一附属医院内分泌代谢科,新疆石河子832000 [2]新疆第二师二十九团医院,新疆库尔勒市841000 [3]石河子大学医学院,新疆石河子832000 [4]新疆医科大学第四附属医院,新疆乌鲁木齐830000

出　　处：《中国现代医学杂志》2018年第32期65-68,共4页China Journal of Modern Medicine

基　　金：区域创新引导计划(No:2018BB040);留学人员科技活动项目择优资助基金(No:2016LX009);兵团中青年科技创新领军人才专项(No:2015BC001)

摘　　要：目的探讨Wnt信号通路中DKK1蛋白在绝经后2型糖尿病(T2DM)女性患者中的表达及其与胰岛素抵抗和胰岛β细胞功能的关系。方法选取2015年10月-2017年10月于石河子大学第一附属医院和新疆维吾尔自治区石河子市第十五社区卫生服务中心住院的绝经后女性T2DM患者。收集患者临床资料并检测常规生化指标、空腹胰岛素(FINS)、空腹C肽(FCP)及DKK1蛋白表达水平,计算胰岛素敏感指数(ISI)、胰岛素抵抗指数(HOMA-IR)及胰岛素β细胞功能指数(HOMA-β)。采用SPSS 20.0统计软件进行数据分析。结果与NGT组相比,T2DM组FPG、果糖胺、HbA1c、TC及HOMA-IR水平提高,FCP、ISI及HOMA-β水平降低(P<0.05)。T2DM组DKK1蛋白表达水平升高(P<0.05)。DKK1蛋白表达水平与FCP呈负相关,与HOMA-IR呈正相关(P<0.05)。FPG、DKK1蛋白是影响FCP及HOMAIR水平的因素(P<0.05)。结论 Wnt信号通路中DKK1蛋白水平的高表达可能参与绝经后女性T2DM患者胰岛素抵抗、胰岛β细胞功能减退的发生发展过程,进而导致绝经后女性T2DM的糖代谢及脂代谢紊乱。Objective To study the expression of DKK1 protein of Wnt signaling pathway,and analyze the relationship of DKK1 expression with insulin resistance and islet beta cell function in postmenopausal women with type 2 diabetes mellitus(T2DM).Methods Postmenopausal women in the First Affiliated Hospital of Shihezi University and the 15th Community Health Service Center of Shihezi City in Xinjiang Uygur Autonomous Region between October 2015 and October 2017 were collected into a NGT group and a T2DM group.The general clinical data and biological indicators were recorded.The levels of conventional biochemical indicators and fasting insulin and fasting c-peptide(FCP)as well as the expression level of DKK1 protein were measured.Insulin sensitivity index(ISI),insulin resistance index(HOMA-IR)and insulinβcell function index(HOMA-β)were calculated.Data was analyzed by SPSS 20.0.Results Compared with the NGT group,FPG,FMN,HbA1c,TC and HOMA-IR increased;however,FCP,ISI and HOMA-βdecreased in the T2DM group(P<0.05).The expression level of DKK1 protein increased in the T2DM group(P<0.05).The serum level of DKK1 protein was negatively correlated with FCP,but positively correlated with HOMA-IR in postmenopausal women with T2DM(P<0.05).FPG and DKK1 protein were the factors influencing FCP and HOMA-IR levels(P<0.05).Conclusions The higher expression of DKK1 protein in Wnt signaling pathway may be involved in the development process of insulin resistance and decreasing islet cell function,thereby leading to the disorders of carbonhydrate and lipid metabolisms in postmenopausal women with T2DM.

关 键 词：绝经后女性 2型糖尿病 DKK1 

分 类 号：R587.1[医药卫生—内分泌]