微小RNA调节间充质干细胞软骨分化机制的研究进展  

Mechanism of microRNA modulation of cartilage differentiation in mesenchymal stem cells

作　　者：冯顶丽 卓丽丹 芦笛[3] 郭红延[2] Feng Dingli;Zhuo Lidan;Lu Di;Guo Hongyan(School and Hospital of Stomatology,Shanxi Medical University,Taiyuan 030001,China;Dept.of Oral Medicine,Beijing Armed Police General Hospital,Beijing 100039,China;Dept.of Orthopedics and Rehabilitation,General Hospital of PLA,Beijing 100853,China)

机构地区：[1]山西医科大学口腔医学院.口腔医院,太原030001 [2]北京武警总医院口腔综合科,北京100039 [3]中国人民解放军总医院整形修复科,北京100853

出　　处：《国际口腔医学杂志》2018年第6期640-645,共6页International Journal of Stomatology

基　　金：国家自然科学基金(81571619);国家重点研发计划(20-16YFE0204400)~~

摘　　要：微小RNA(miRNA)主要通过不完全的碱基配对,在转录后水平调控基因的表达。在间充质干细胞软骨向分化过程中,有许多不同miRNA的表达,其对软骨分化起着重要的调节作用。近年来,miRNA具有成为软骨疾病治疗靶点的可能性,促进了研究人员强有力的调查,以求深入地了解miRNA在软骨发育中的作用机制。本文结合相关文献,对间充质干细胞软骨向分化过程中miRNA的表达及某些miRNA在调控软骨分化过程中的具体作用途径进行综述。microRNAs(miRNAs)regulate gene expression at the post-transcriptional level mainly through incomplete base-pairing.There are many different miRNA expressions in mesenchymal stem cells during the process of differentiation,and such expressions play an important role in the regulation of cartilage differentiation.In recent years,the possibility of miRNA becoming a target for the treatment of cartilage diseases has prompted researchers to investigate the role of miRNAs in the development of cartilage.In this paper,we review the expression of miRNAs during differentiation of mesenchymal stem cell cartilage and the specific roles of miRNAs in the process of cartilage differentiation.

关 键 词：微小RNA 间充质干细胞 软骨分化 靶基因 

分 类 号：Q254[生物学—细胞生物学]