感冒退热合剂治疗风热型感冒的免疫调节作用研究  

Immunoregulation effect of cold-fever-treating mixture on wind-heat type common cold

作　　者：周林[1] 喻灿[2] 刘毓玲[1] 陈奕雯[1] ZHOU Lin;YU Can;LIU Yuling;CHEN Yiwen(Department of Clinical Laboratory,Wuhan Hospital of Traditional Chinese Medicine,Wuhan,Hubei 430050,China;Department of Emergency,Wuhan Hospital of Traditional Chinese Medicine,Wuhan,Hubei 430050,China)

机构地区：[1]武汉市中医医院检验科,湖北武汉430050 [2]武汉市中医医院急诊科,湖北武汉430050

出　　处：《国际检验医学杂志》2018年第21期2618-2621,共4页International Journal of Laboratory Medicine

基　　金：武汉市卫生和计划生育委员会临床医学科研项目(WZ15C13);武汉市中青年人才骨干项目(武卫生计生[2016-59])

摘　　要：目的探讨感冒退热合剂治疗风热型感冒的免疫调节作用。方法 120例风热型感冒患者,采用随机数字表法随机分为治疗组和对照组,每组各60例,分别给予感冒退热合剂和双黄连口服液治疗。比较两组患者治疗前后血清免疫球蛋白、外周血淋巴细胞亚群的变化以及临床症状改善程度。结果 120例患者中,6例在治疗过程中服用解热镇痛药被剔除,2例未能联系失访,最终完成观察病例112例,其中治疗组和对照组各56例。两组患者治疗前后的免疫球蛋白水平变化,差异无统计学意义(P>0.05);治疗组治疗后淋巴细胞亚群CD3^+、CD4^+、CD8^+百分比均较治疗前明显升高(P<0.05);CD4^+/CD8^+、CD19^+、NK治疗前后相比,差异无统计学意义(P>0.05);治疗组治疗后CD3^+、CD4^+、CD8^+百分比均较对照组治疗后明显升高(P<0.05)。两组患者治疗前症状总积分比较,差异无统计学意义(P>0.05),治疗组治疗后症状总积分较对照组治疗后降低(P<0.05)。治疗组总有效率优于对照组(P<0.05)。结论感冒退热合剂通过调节外周血淋巴细胞亚群增强患者免疫功能,对治疗风热型感冒疗效显著。Objective To study the immunoregulation effect of cold-fever-treating mixture on wind-heat type common cold.Methods Totally 120 cases of wind-heat type common cold patients were randomly divided into treatment group and control group,60 cases in each group,treatment group were treated with cold-fever-treating mixture while control group were treated with shuanghuanglian oral liquid.The changes of immunoglobulins,lymphocyte subsets and clinical symptoms improved were compared before and after treatment.Results Of the 120 patients,6 were excluded from taking antipyretic and analgesic drugs during the treatment,2 failed to contact the missing visit,and 112 cases were finally observed,including 56 cases in the treatment group and 56 cases in the control group.There was no significant difference of immunoglobulins between the two groups(P>0.05).After treatment,the percentage of CD3+、CD4+、CD8+was significantly increased in patients than those of before treatment in treatment group(P<0.05).The percentage of CD3+/CD4+、CD19+、NK had no difference compared before and after treatment in the treatment group(P>0.05).Compared with the control group,the percentage of CD3+、CD4+、CD8+was significantly increased in treatment group after treatment(P<0.05).There was no significant difference in total symptom score between the two groups before treatment(P>0.05).The total symptom score of the treatment group was lower than that of the control group after treatment(P<0.05).The total effective rate of the treatment group was better than that of the control group(P<0.05).Conclusion Cold-fever-treating mixture may treat the patients with wind-heat type common cold by regulating lymphocyte subsets,has a significant effect on treating wind-heat type common cold.

关 键 词：感冒退热合剂 风热型感冒 双黄连口服液 淋巴细胞亚群 免疫调节 

分 类 号：R451[医药卫生—治疗学] R283[医药卫生—临床医学]