心脏手术患者Sonoclot分析与常规凝血试验的相关性研究  

Sonoclot analysis in patients with cardiac surgery and its correlation with conventional coagulation tests

作　　者：陶翠华[1] 陈佑平[1] 杜佳 凃茹[1] 张真路[1] TAO Cuihua;CHEN Youping;DU Jia;TU Ru;ZHANG Zhenlu(Department of Laboratory Medicine,Wuhan Asia Heart Hospital,Wuhan,Hubei 430022,China)

机构地区：[1]武汉亚洲心脏病医院检验医学中心,湖北武汉430022

出　　处：《国际检验医学杂志》2018年第21期2622-2625,2629,共5页International Journal of Laboratory Medicine

基　　金：武汉市卫生和计划生育委员会科研基金资助课题(WX17D45)

摘　　要：目的探讨Sonoclot分析仪检测指标与常规凝血试验凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)和纤维蛋白原含量(FIB)及血小板(PLT)计数的相关性。方法回顾性分析该院281例心脏手术患者Sonoclot检测激活凝血时间(ACT)、凝血速率(CR)和血小板功能(PF)结果以及常规凝血试验PT、APTT、TT、FIB和PLT结果,将Sonoclot检测的参数与常规凝血试验结果和PLT计数结果进行相关性分析,并对相关的参数进一步做回归分析,评估各参数之间的关系。结果 ACT与APTT和TT均呈显著正相关,相关系数、P值和回归方程分别为r=0.622,P<0.01,Y=1.524 X+118.184;r=0.528,P<0.01,Y=2.076 X+141.336。ACT与PT、FIB和PLT无显著相关关系。CR与APTT和TT均呈显著负相关,相关系数、P值和回归方程分别为r=-0.433,P<0.01,Y=-0.193 X+30.344;r=-0.415,P<0.01,Y=-0.296 X+28.164。CR与FIB和PLT均呈显著正相关,相关系数、P值和回归方程分别为r=0.449,P<0.01,Y=8.241 X+5.757;r=0.206,P<0.01,Y=0.041 X+16.376。PF与PT和APTT呈显著负相关,相关系数、P值和回归方程分别为r=-0.209,P<0.01,Y=-0.098 X+3.385;r=-0.213,P<0.01,Y=-0.010 X+2.558。PF与FIB和PLT呈显著正相关,相关系数、P值和回归方程分别为r=0.389,P<0.01,Y=0.771 X+0.608;r=0.615,P<0.01,Y=0.013 X+0.392。Sonoclot检测参数之间,ACT与CR和PF呈显著负相关,CR与PF之间呈显著正相关,相关系数、P值分别为r=-0.644,P<0.01;r=-0.196,P<0.01;r=0.528,P<0.01。结论心脏手术患者中,Sonoclot参数与常规凝血参数在监测凝血过程和状态上有显著相关性,Sonoclot分析参数之间存在显著相关性。Objective To investigate the correlation between Sonoclot analyzer and prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),fibrinogen content(FIB)and platelet(PLT)count in conventional coagulation test.Methods The results of activated coagulation time(ACT),coagulation rate(CR)and platelet function(PF)detected by Sonoclot and the results of PT,APTT,TT,FIB and PLT in 281 patients undergoing cardiac surgery were retrospectively analyzed.Correlation analysis was made between the parameters of Sonoclot test and the results of conventional coagulation test and PLT count,and regression analysis was made to evaluate the relationship between the parameters.Results ACT was positively correlated with APTT and TT,the correlation coefficient,P value and regression equation were r=0.622,P<0.01,Y=1.524 X+118.184;r=0.528,P<0.01,Y=2.076 X+141.336,respectively.There was no significant correlation between ACT and PT,FIB,PLT.CR was negatively correlated with APTT and TT,the correlation coefficient,P value and regression equation were r=-0.433,P<0.01,Y=-0.193 X+30.344;r=-0.415,P<0.01,Y=-0.296 X+28.164,respectively.CR was positively correlated with FIB and PLT,the correlation coefficient,P value and regression equation were r=0.449,P<0.01,Y=8.241 X+5.757;r=0.206,P<0.01,Y=0.041 X+16.376,respectively.PF was negatively correlated with PT and APT,the correlation coefficient,P value and regression equation were r=-0.209,P<0.01,Y=-0.098 X+3.385;r=-0.213,P<0.01,Y=-0.010 X+2.558,respectively.PF was positively correlated with FIB and PLT,the correlation coefficient,P value and regression equation were r=0.389,P<0.01,Y=0.771 X+0.608,r=0.615,P<0.01,Y=0.013 X+0.392,respectively.ACT was negatively correlated with CR and PF,and CR was positively correlated with PF,the correlation coefficients,P value were:r=-0.644,P<0.01;r=-0.196,P<0.01,r=0.528,P<0.01,respectively.Conclusion In patients undergoing cardiac surgery,there is a significant correlation between Sonoclot parameters and conventional coagulation parameters in

关 键 词：Sonoclot分析 心脏手术 凝血试验 

分 类 号：R541[医药卫生—心血管疾病] R446.1[医药卫生—内科学]