尿酸联合糖化血红蛋白早期检测对高龄孕妇妊娠期糖尿病发病的预测  

Early detection of uric acid combined with glycosylated hemoglobin for predicting the incidence of gestational diabetes in elderly pregnant women

作　　者：李华[1] 殷红梅[2] 李英[2] LI Hua;YIN Hongmei;LI Ying(Diabetes Department,Shengli Oilfield Headquarters Hospital,Dongying,Shandong,China,257000;Obstetrics Department,Shengli Oilfield Central Hospital,Dongying,Shandong,China,257000)

机构地区：[1]胜利油田机关医院糖尿病科,山东东营257000 [2]胜利油田中心医院产科,山东东营257000

出　　处：《分子诊断与治疗杂志》2018年第6期411-416,共6页Journal of Molecular Diagnostics and Therapy

摘　　要：目的探讨尿酸联合糖化血红蛋白在高龄孕妇妊娠期糖尿病中的预测效果。方法回顾性收集2016年6月至2017年6月胜利油田中心医院产科门诊诊断妊娠糖尿病患者120例,设为实验组;选取同期产检的健康高龄孕妇120例,设为对照组,于12~16周完善相关检查,包括:BMI、孕周等;采用酶联比色法测定2组血糖水平;采用高效液相法测定2组糖化血红蛋白水平;采用X7全自动生化分析仪检测2组尿酸水平;采用多因素Logistic对妊娠期糖尿病患者与尿酸、糖化血红蛋白水平进行多因素分析。结果实验组高龄孕妇妊娠期糖尿病患者BMI、FPG、糖化血红蛋白水平,均高于对照组(P<0.05),实验组高龄孕妇妊娠期糖尿病患者尿酸水平偏高,但与对照组比较无明显差异(P>0.05);尿酸与糖化血红蛋白单一指标用于高龄孕妇妊娠期糖尿病灵敏度及特异度比较无统计学意义(P>0.05);尿酸联合糖化血红蛋白用于高龄孕妇妊娠期糖尿病灵敏度及特异度,均高于单一尿酸、糖化血红蛋白(P<0.05);多因素Logistic分析结果表明:妊娠期糖尿病患者妊娠结局与糖化血红蛋白、尿酸水平具有统计学意义(P<0.05);ROC曲线可以看出:尿酸联合糖化血红蛋白诊断时曲线下面积最大,其次为糖化血红蛋白,最后为尿酸;实验组高龄孕妇妊娠期糖尿病患者不良妊娠结局发生率为10.00%,高于对照组5.00%(P<0.05)。结论将尿酸联合糖化血红蛋白用于高龄孕妇妊娠期糖尿病发病中效果理想,能反应患者疾病严重程度,为临床治疗提供依据和参考,值得推广应用。Objective To investigate the predictive effect of uric acid combined with glycosylated hemoglobin in gestational diabetes in elderly pregnant women.Methods A retrospective collection of 120 cases of gestational diabetes mellitus diagnosed in the obstetrics outpatient department of Shengli Oilfield Central Hospital from June 2016 to June 2017 was set as the experimental group,while 120 healthy pregnant women were selected as the control group at the same time.The relevant examinations were completed in 12~16 weeks,including:BMI,gestational age,etc.;blood glucose levels were measured by enzyme-linked colorimetry;the levels of glycated hemoglobin were measured by high performance liquid phase method;uric acid levels were detected by X7 automatic biochemical analyzer;multivariate analysis of uric acid and glycosylated hemoglobin levels in pregnant women with GDM was perform by multivariate Logistic analysis.Results In the experimental group,the levels of BMI,FPG and glycosylated hemoglobin in pregnant women with gestational diabetes were higher than those in the control group(P<0.05).In the experimental group,the uric acid level of pregnant women with gestational diabetes was higher,but there was no significant difference between the 2 groups(P>0.05).There was no significant difference in the sensitivity and specificity of uric acid and glycosylated hemoglobin in the diagnosis of gestational diabetes in elderly women(P>0.05).Uric acid combined with glycosylated hemoglobin was used in the pregnancy of pregnant women.The sensitivity and specificity of diabetes were higher than that of single uric acid and glycosylated hemoglobin(P<0.05).Multivariate logistic analysis showed that the pregnancy outcome and glycosylated hemoglobin and uric acid levels in gestational diabetes patients were statistically significant(P<0.05).The area under the ROC curve of uric acid combined with glycosylated hemoglobin is the largest,followed by glycated hemoglobin,and finally uric acid;the incidence of adverse pregnancy outcome in pregnant

关 键 词：尿酸 糖化血红蛋白 高龄孕妇妊娠期糖尿病 

分 类 号：R714.256[医药卫生—妇产科学]