雄黄的安全性评价和配伍减毒研究  

Evaluation on Realgar Safety and Reducing Toxicity

作　　者：何溶溶 吕翔[1] 周婧[1] 马宏跃[1] 严燕青 王恒斌 狄留庆[1] 段金廒[1] HE Rong rong;LV Xiang;ZHOU Jing;MA Hong yue;YAN Yan qing;WANG Heng bin;DI Liu qing;DUAN Jin ao(School of Pharmacy,Nanjing University of Chinese Medicine,Jiangsu Key Laboratory for High Technology Research of TCM Formulae Research,Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Jiangsu Province,Nanjing,210023,China;Leiyunshang Pharmaceutical Group Co.LTD,Suzhou,215009,China)

机构地区：[1]江苏省方剂高技术研究重点实验室/江苏省中药资源产业化过程协同创新中心,南京中医药大学药学院,江苏南京210023 [2]雷允上药业集团有限公司,江苏苏州215009

出　　处：《南京中医药大学学报》2018年第6期645-648,共4页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省科技厅产学研项目(BY201500801);江苏省方剂高技术研究重点实验室/江苏省中药资源产业化过程协同创新中心资助项目(FJGJS201515,ZDXM114);江苏省六大人才高峰C类(YY015);江苏高校优势学科建设工程资助项目(PAPD);六神丸质量标准化研究(BA2016104,ZYBZHCJS30);国家自然科学基金(81673563,81274199)

摘　　要：雄黄是经典中成药的常见组成药物,因含有硫化砷类成分,其安全性备受关注。介绍了近年国内外对砷存在形式、毒性分子机制基础上,结合含雄黄制剂的临床不良反应报道,探讨了雄黄慢性暴露对实验动物的安全性和减毒研究。并以经典名方六神丸为例,表明方剂配伍对雄黄的减毒效果。提示雄黄制剂在临床合理剂量、用药时间和组方配伍情况下,存在一定安全性。Realgar is a common component of classical Chinese medicine preparation,which has attracted much attention due to high content of arsenic sulfide.This reviewed the research on the species,toxicity and molecular mechanism of arsenic in recent years.The clinical adverse effects of realgar containing preparations and the safety of realgar on chronic exposure to experimental animals were analyzed.In particular,the classic Chinese medicine Liushen Wan compatibility reduced realgar induced toxicity.That illustrated that the Chinese medicine preparations containing realgar clinically used at low dose and reasonable medication time,have certain drug safety.

关 键 词：雄黄 砷 六神丸 配伍减毒 

分 类 号：R282.76[医药卫生—中药学]