多溶剂溶析冷却结晶法提纯莱鲍迪甙A的工艺研究  

Purification of Rebaudioside A by Mixed Solventing-out Cooling Crystallization

作　　者：毛娅[1] 

机构地区：[1]四川化工职业技术学院,四川泸州646009

出　　处：《化工设计通讯》2018年第11期145-146,共2页Chemical Engineering Design Communications

摘　　要：采用一步多溶剂溶析冷却结晶法提纯莱鲍迪甙A,考察了不同溶析剂及其组合对莱鲍迪甙A的结晶收率及纯度影响。结果表明,RA55在含有异丙醇与乙酸乙酯混合溶析剂的90%乙醇水溶液的一步溶析冷却结晶工艺中,制得的莱鲍迪甙A纯度达到99%以上,产品总收率达到73.5%,展现出良好的提纯效果和经济性。Rebaudioside A(RA)was purified by mixed solventing-out cooling crystallization method.Effects of the kind and combination of anti-solvent on purity and crystallization yield of RA were discussed.The results showed that the purity of RA reached 99%and the crystallization yield of RA was up to 73.5%in ethanol-isopropanol-ethyl acetate-water system.

关 键 词：莱鲍迪甙A 溶析冷却结晶 混合溶剂 

分 类 号：TQ645.98[化学工程—精细化工]