MRS观察原发性夜间遗尿症患儿丘脑GABA代谢异常  

MRS observation of thalamicγ-aminobutyric acid in children with primary nocturnal enuresis

作　　者：游弋 黄明珠[1] 张旭[1] 侯阳[1] 于兵[1] YOU Yi;HUANG Mingzhu;ZHANG Xu;HOU Yang;YU Bing(Department of Radiology,Shengjing Hospital of China Medical University, Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院放射科,辽宁沈阳110004

出　　处：《中国医学影像技术》2018年第11期1637-1640,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家重点研发计划数字诊疗装备研发重点专项(2016YFC0107106;2016YFC0106804);国家自然科学基金(81541058;81301204)

摘　　要：目的采用MEGA-PRESS MRS探讨原发性夜间遗尿症(PNE)患儿丘脑γ-氨基丁酸(GABA)浓度异常。方法对35例PNE患儿(PNE组)及35名正常儿童(对照组)行MEGA-PRESS MRS扫描。以Gannet 3.0软件包获得丘脑GABA浓度。以Mann-Whitney U检验比较2组间丘脑GABA浓度差异,以Spearman相关分析评价PNE患儿丘脑GABA浓度与唤醒难度(AS)评分的相关性。结果 PNE患儿丘脑GABA浓度及AS评分均高于对照组(Z=2.337、2.821,P=0.019、0.005);相关分析显示PNE患儿丘脑GABA浓度与AS评分呈正相关(r=0.886,P=0.001)。结论PNE患儿丘脑GABA浓度异常升高可能与PNE发病有关。Objective To investigateγ-aminobutyric acid(GABA)level of the thalamus in children with primary nocturnal enuresis(PNE)using MEGA-PRESS MRS.Methods MEGA-PRESS MRS were performed,and arousal from sleep(AS)scores were obtained in 35 PNE pediatric patients(PNE group)and 35 healthy controls(control group).GABA levels of thalamus were post-processed using Gannet 3.0 software package and compared between the 2 groups with Mann-Whitney U test.Spearman correlation analysis was performed to evaluate the correlation between GABA levels and AS scores in PNE group.Results Both AS scores and GABA levels of PNE group were significantly higher than those of the control group(Z=2.337,2.821,P=0.019,0.005).GABA level of thalamus also showed positive correlation with the AS scores in PNE group(r=0.886,P=0.001).Conclusion The abnormal increased GABA level of thalamus may positively associated with the pathogenesis of PNE.

关 键 词：夜遗尿症 儿童 Γ氨基丁酸 丘脑 磁共振波谱 

分 类 号：R725[医药卫生—儿科] R445.2[医药卫生—临床医学]