弓形虫感染与阿尔茨海默病相关性的研究进展  

Advances on the association between Toxoplasma gondii infection and Alzheimer's disease

作　　者：郑斌[1] 李金娜[1] ZHENG Bin;LI Jin-na(Department of Parasitology,Xinxiang Medical University,Henan 453003,China)

机构地区：[1]新乡医学院寄生虫学教研室,新乡453003

出　　处：《中国人兽共患病学报》2018年第10期931-935,共5页Chinese Journal of Zoonoses

基　　金：河南省科技厅科技攻关项目(No.172102310404);新乡市科技局科技攻关项目(No.GXGG16017);新乡医学院博士科研启动基金项目(No.100777)~~

摘　　要：阿尔茨海默病(Alzheimers disease,AD)是老年人常见的一种中枢神经系统退行性疾病,AD的发病机制尚未完全阐明。多项研究发现:AD患者血清弓形虫抗体阳性率高于对照组;弓形虫感染可诱发或加重认知障碍、记忆进行性减退等AD样症状;弓形虫感染引起脑组织Aβ沉积、Tau蛋白高度磷酸化和神经元损伤等AD样病变。研究结果提示弓形虫感染与AD具有关联性。本文就弓形虫感染与AD相关性的研究进展做一综述。Alzheimer s disease(AD)is a progressive neurodegenerative disease,and the pathogenesis of AD has not been fully elucidated.Patients with AD had higher seropositivity rates for anti-Toxoplasma gondii(T.gondii)IgG antibodies compared to healthy controls.T.gondii infection caused AD-like symptoms(cognitive impairment,memory loss);infected wild-type mice showed major signs of AD including Aβdeposition,pTau expression,and neuronal loss.Results of researches indicate a possible link between T.gondii infection and AD.In this review,we summarized recent advances on the association between T.gondii infection and AD.

关 键 词：刚地弓形虫 阿尔茨海默病 Β-淀粉样蛋白 TAU蛋白 神经元 

分 类 号：R382.5[医药卫生—医学寄生虫学]