大肠杆菌ABC转运体研究进展  

Progress on research of ATP-binding cassette transporters in Escherichia coli

作　　者：冯振月[1] 刘德福 崔玉东[1] FENG Zhen-yue;LIU De-fu;CUI Yu-dong(Heilongjiang Bayi Agricultural University,Daqing 163319,China;Daqing Branch of Heilongjiang Academy of Sciences,Daqing163000,China)

机构地区：[1]黑龙江八一农垦大学,大庆163319 [2]黑龙江省农科院大庆分院,大庆163000

出　　处：《中国人兽共患病学报》2018年第10期944-949,960,共7页Chinese Journal of Zoonoses

基　　金：黑龙江八一农垦大学校内创新训练项目(No.XC2015045)~~

摘　　要：ABC转运体是整合膜蛋白,穿过细胞膜转运物质,其广泛分布于细菌、真菌和真核生物体内。最近发表的ATP酶结构域、底物结合蛋白及全长转运体的晶体结构[1]对我们认识转运体的分子结构提供了新的依据。生物信息学方法可确定大肠杆菌的所有转运体以及它们与其它已知转运体的关系,本文就从已经获得的结构数据及构象推测主要集中对大肠杆菌ABC转运体研究进展做一综述。ATP-binding cassette(ABC)transporters are integral membrane proteins that actively transport molecules across cell membranes.The ABC is a wide variety of physiological processes in all eukaryotic,archaebacterial and eubacterial species.Recent crystal structures of a number of ATPase domains,substrate binding proteins,and full-length transporters have given new insight in the molecular basis of transport.Bioinformatics approaches allow an approximate identification of all ABC transporters in E.coli and their relation to other known transporters.Computational approaches involving modeling and simulation are beginning to yield insight into the dynamics of the transporters.We summarize the function of the known ABC transporters in E.coli and mechanistic insights from structural and computational studies.

关 键 词：ABC转运体 大肠杆菌 研究进展 

分 类 号：R378.2[医药卫生—病原生物学]