绝经女性良性阵发性位置性眩晕患者骨密度、血钙浓度及维生素D水平分析  

Analysis of Bone Mineral Density,Serum Calcium Concentration and Vitamin D Status in Postmenopausal Women with Benign Paroxysmal Positional Vertigo

作　　者：张秀玲[1] 周宁霞[1] 陈金湘[1] 吴海燕[1] Zhang Xiuling;Zhou Ningxia;Chen Jinxiang;Wu Haiyan(Department of Otolaryngology,the Affiliated Jiangyin Hospital of Southeast University Medical College,Jiangyin,214400,China)

机构地区：[1]东南大学医学院附属江阴医院耳鼻咽喉科,江阴214400

出　　处：《听力学及言语疾病杂志》2018年第6期576-579,共4页Journal of Audiology and Speech Pathology

基　　金：无锡市卫生计生科研项目(MS201714)

摘　　要：目的探讨绝经后女性良性阵发性位置性眩晕(benign paroxysmal positional vertigo,BPPV)患者BPPV的发生和复发与骨密度、血钙及血清维生素D浓度的相关性。方法选取2014年1月至2016年12月就诊于东南大学附属江阴医院耳鼻喉科门诊且明确诊断为原发性BPPV的78例(78耳)绝经后女性患者为试验组,根据随访结果分为BPPV未复发组(63例)和BPPV复发组(15例),选取同期来院体检的自然绝经1年的正常女性30例为对照组。采用双能射线吸收法检测所有受试者腰椎骨密度,抽取清晨空腹外周静脉血4ml,分别运用半自动分析仪和免疫化学发光法检测血钙浓度和血清维生素D水平。比较各组间骨密度、血钙浓度和血清维生素D水平。结果试验组骨密度下降者占82.15%(64/78),高于对照组(23.33%,7/30),差异有统计学意义(P<0.001)。BPPV复发组骨密度T值最低(-1.77±0.63),其次为BPPV未复发组(-1.29±0.82),对照组为-0.63±0.92,组间差异有统计学意义(P<0.001)。三组间的血钙浓度差异无统计学意义(P=0.71)。对照组的血清维生素D水平(23.98±2.12ng/ml)高于BPPV未复发组(18.45±4.28ng/ml)和BPPV复发组(17.15±6.04)ng/ml,差异有统计学意义(P<0.001),BPPV未复发组与复发组之间差异无统计学意义(P>0.05)。结论绝经后女性BPPV患者BPPV的发生可能与骨密度及血清维生素D水平下降有关,而与血钙浓度可能无关;绝经后女性患者BPPV的复发则仅与骨密度下降有关。Objective To study the correlation between the bone mineral density,blood calcium and serum vitamin D and benign paroxysmal positional vertigo(BPPV)in postmenopausal women with BPPV.Methods Seventy eight cases of menopausal women previously diagnosed as primary BPPV in Department of ENT of Jiangyin Hospital Affiliated to Southeast University from January 2014 to December 2016 were selected as the experimental group and thirty cases of normal women with natural menopause for one year with non-BPPV were selected as the control group.According to the results of follow-up,the experimental group was divided into the BPPV nonrecurrent group and the BPPV recurrent group.The bone mineral density(BMD)of the lumbar spine was measured by double energy ray absorption method,the blood calcium concentration and serum level of 25(OH)D were measured in the early morning.Results Compared with the control group,bone mineral density significantly decreased in 64 cases(82.15%)in the BPPV group.The T-score was the lowest in the BPPV recurrent group,followed by the BPPV nonrecurrent group.There was no significant difference in the concentration of blood calcium within the three groups.The serum level of 25(OH)D in the control group was higher than that in the BPPV nonrecurrent group and the BPPV recurrent group.The difference was statistically significant.There was no significant difference between the BPPV nonrecurrent group and the BPPV recurrent group.Conclusion The incidence of BPPV in postmenopausal women is related to low bone densities and low vitamin D levels,but not to the concentration of blood calcium.The recurrence of BPPV in postmenopausal women is only associated with low bone mineral density.

关 键 词：良性阵发性位置性眩晕 绝经 骨密度 血钙 维生素D 

分 类 号：R764.21[医药卫生—耳鼻咽喉科]