Acute dapsone poisoning in a 3-year-old child: Case report with review of literature  

作　　者：Menon Narayanankutty Sunilkumar Thekkuttuparambil Ananthanarayanan Ajith Vadakut Krishnan Parvathy 

机构地区：[1]Department of Paediatrics,Amala Institute of Medical Sciences [2]Department of Biochemistry,Amala Institute of Medical Sciences

出　　处：《World Journal of Clinical Cases》2015年第10期911-914,共4页世界临床病例杂志

摘　　要：Dapsone(DDS-diamino diphenyl sulphone) is a sulfone antibiotic being used for a variety of clinical conditions. Poisoning in children by DDS is rarely reported. Poisoning in acute cases will be frequently unrecognized due to relative lack of severe signs and symptoms. Methemoglobinemia is the major life-threatening situation associated with poisoning of DDS. Hence, any delay for medical attention can lead to increased rate of mortality. In this case, we describe acute DDS poisoning in a 3-year-old child and the successful management using intravenous methylene blue.Dapsone(DDS-diamino diphenyl sulphone) is a sulfone antibiotic being used for a variety of clinical conditions. Poisoning in children by DDS is rarely reported. Poisoning in acute cases will be frequently unrecognized due to relative lack of severe signs and symptoms. Methemoglobinemia is the major life-threatening situation associated with poisoning of DDS. Hence, any delay for medical attention can lead to increased rate of mortality. In this case, we describe acute DDS poisoning in a 3-year-old child and the successful management using intravenous methylene blue.

关 键 词：DAPSONE METHEMOGLOBINEMIA Ascorbic acid METHYLENE blue HEMOLYSIS 

分 类 号：R725.9[医药卫生—儿科]