Sleep disordered breathing in interstitial lung disease: A review  

作　　者：Lauren K Troy Tamera J Corte 

机构地区：[1]Department of Respiratory Medicine, Royal Prince Alfred Hospital, Camperdown, Sydney NSW 2050, Australia [2]Sydney Medical School, University of Sydney, Sydney NSW 2006, Australia

出　　处：《World Journal of Clinical Cases》2014年第12期828-834,共7页世界临床病例杂志

基　　金：Supported by An Australian Postgraduate Award through the University of Sydney(Troy LK is supported)

摘　　要：Patients with interstitial lung disease commonly exhibit abnormal sleep architecture and increased sleep fragmentation on polysomnography. Fatigue is a frequent complaint, and it is likely that poor sleep quality is a significant contributor. A number of studies have shown that sleep disordered breathing is prevalent in this population, particularly in the idiopathic pulmonary fibrosis subgroup. The factors that predispose these patients to obstructive sleep apnoea are not well understood, however it is believed that reduced caudal traction on the upper airway can enhance collapsibility. Ventilatory control system instability may also be an important factor, particularly in those with increased chemo-responsiveness, and in hypoxic conditions. Transient, repetitive nocturnal oxygen desaturation is frequently observed in interstitial lung disease, both with and without associated obstructive apnoeas. There is increasing evidence that sleep-desaturation is associated with increased mortality, and may be important in the pathogenesis of pulmonary hypertension in this population.Patients with interstitial lung disease commonly exhibit abnormal sleep architecture and increased sleep fragmentation on polysomnography. Fatigue is a frequent complaint, and it is likely that poor sleep quality is a significant contributor. A number of studies have shown that sleep disordered breathing is prevalent in this population, particularly in the idiopathic pulmonary fibrosis subgroup. The factors that predispose these patients to obstructive sleep apnoea are not well understood, however it is believed that reduced caudal traction on the upper airway can enhance collapsibility. Ventilatory control system instability may also be an important factor, particularly in those with increased chemo-responsiveness, and in hypoxic conditions. Transient, repetitive nocturnal oxygen desaturation is frequently observed in interstitial lung disease, both with and without associated obstructive apnoeas. There is increasing evidence that sleep-desaturation is associated with increased mortality, and may be important in the pathogenesis of pulmonary hypertension in this population.

关 键 词：SLEEP DISORDERED breathing INTERSTITIAL lung disease Pulmonary fibrosis NOCTURNAL hypoxia OBSTRUCTIVE SLEEP APNOEA 

分 类 号：R766[医药卫生—耳鼻咽喉科]