合并慢性乙型肝炎病毒感染的药物性肝损伤的临床特点分析  

Clinical characteristics of drug-induced liver injury with chronic hepatitis B virus infection

作　　者：周维珍 王代梅[2] ZHOU Wei-zhen;WANG Daimei(Chengdu Qingbaijiang District People s Hospital,Chengdu 610300,China;Suining Central Hospital,Suining 629000,China)

机构地区：[1]成都市青白江区人民医院,四川成都610300 [2]四川省遂宁市中心医院,四川遂宁629000

出　　处：《实用医院临床杂志》2018年第6期120-122,共3页Practical Journal of Clinical Medicine

摘　　要：目的探讨合并慢性乙型肝炎病毒感染的药物性肝损伤的临床特点。方法回顾我院收治的96例药物性肝损伤患者的临床资料,分为单纯药物性肝损伤组(DILI组,n=50)和合并乙型肝炎病毒感染的药物性肝损伤组(DILI+HBV组,n=46),对比分析两组的临床特点。结果 DILI+HBV组年龄小于DILI组,损伤类型以肝细胞型为主、混合型次之,且病情较DILI组重(P <0. 05)。两组造成肝损伤的药物均主要为中药、抗感染药和解热镇痛药,临床症状均主要表现为乏力、黄疸、恶心、腹胀及食欲不振。结论合并慢性乙型肝炎病毒感染的药物性肝损伤病情较单纯性肝损伤重,但其致损伤药物类型及临床症状与单纯药物性肝损伤相比没有特异性。To explore the clinical characteristics of drug-induced liver injury(DILI)with chronic hepatitis B virus(HBV)infection.Clinical data of 96 patients with drug-induced liver injury admitted to our hospital were retrospectively analyzed.The patients were divided into DILI group(n=50)and DILI+HBV group(n=46).Then,the clinical features of the two groups were compared.The age of patients in the DILI+HBV group was significantly younger than that of the DILI group.The lesion types of the DILI+HBV group were mainly hepatocyte type and mixed type,and the condition was more severe than the DILI group(P<0.05).The drugs leading to liver injury were mainly Chinese medicines,anti-infective agents and antipyretic analgesics.The clinical symptoms were mainly manifested as jaundice,nausea,abdominal distension and loss of appetite.Drug-induced liver injury with chronic hepatitis B virus infection has certain age and gender differences,and its condition is more severe than the simple liver injury.However,no specificity in the drug type and clinical symptoms are found between the two types of the disease.

关 键 词：慢性乙型肝炎病毒感染 药物性肝损伤 临床特点 

分 类 号：R512.62[医药卫生—内科学]