Antimicrobial technology in orthopedic and spinal implants  

作　　者：Adam EM Eltorai Jack Haglin Sudheesha Perera Bielinsky A Brea Roy Ruttiman Dioscaris R Garcia Christopher T Born Alan H Daniels 

机构地区：[1]Warren Alpert Medical School, Brown University [2]Department of Biology, Brown University [3]Center for Biomedical Engineering,Brown University [4]Department of Orthopaedic Surgery, Warren Alpert Medical School, Brown University

出　　处：《World Journal of Orthopedics》2016年第6期361-369,共9页世界骨科杂志（英文版）

摘　　要：Infections can hinder orthopedic implant function and retention.Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion.Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems,material science,immunology,and polymer chemistry are in development and early clinical use.This review outlines orthopedic implant antimicrobial technology,its current applications and supporting evidence,and clinically promising future directions.Infections can hinder orthopedic implant function and retention.Current implant-based antimicrobial strategies largely utilize coating-based approaches in order to reduce biofilm formation and bacterial adhesion.Several emerging antimicrobial technologies that integrate a multidisciplinary combination of drug delivery systems,material science,immunology,and polymer chemistry are in development and early clinical use.This review outlines orthopedic implant antimicrobial technology,its current applications and supporting evidence,and clinically promising future directions.

关 键 词：ANTIMICROBIAL Coated IMPLANTS Antibiotic ANTISEPTIC NANO-SILVER Photoactive 

分 类 号：R687[医药卫生—骨科学]