病原菌影响巨噬细胞极化的研究进展  

Advances in the study of pathogens affect macrophage polarization

作　　者：张焱皓 龙润莹 刘旭恒[1] 刘芊伊 李茂 罗军敏(指导教师)[1] ZHANG Yan-Hao;LONG Run-Ying;LIU Xu-Heng;LIU Qian-Yi;LI Mao;LUO Jun-Min(Department of Immunology,Zunyi Medical College,Immune Molecules Application Research Center in Guizhou Province,Zunyi 563003,China)

机构地区：[1]遵义医学院免疫学教研室,贵州省免疫分子应用研究工程中心,遵义563003

出　　处：《中国免疫学杂志》2018年第11期1748-1752,1761,共6页Chinese Journal of Immunology

基　　金：本文为国家自然科学基金地区项目(81460249,81860291);贵州省科学技术厅科技计划项目(黔科合基础[2018]1192)。

摘　　要：巨噬细胞作为固有免疫系统中的重要一员,具有吞噬、抗原呈递、杀伤病原体等功能,在早期控制病原菌感染中发挥重要作用。病原菌可诱导巨噬细胞发生M1/M2型极化而参与机体对病原菌感染的免疫应答。病原菌运用不同的策略诱导巨噬细胞极化,对感染性疾病转归产生重要的影响。Macrophages,an important member of the innate immune system,have the functions of phagocytosis,antigen presentation and pathogen killing and play an important role in the early control of pathogen infection.Pathogen can induce M1/M2 macrophages polarization and participate in the body′s immune response to pathogen infection.Pathogens use different strategies to induce macrophage polarization and have an important impact on the outcome of infectious diseases.

关 键 词：巨噬细胞 极化 病原菌 

分 类 号：R392.12[医药卫生—免疫学]