非诺贝特联合二甲双胍治疗2型糖尿病的疗效分析  

Effect of Enofibrate combined with Metformin on type 2 diabetes mellitus

作　　者：张云娜[1] 付冬霞[1] 郭宁宁[1] 赵乃蕊[1] 许金秀[1] 王光亚[1] Yun-na Zhang;Dong-xia Fu;Ning-ning Guo;Nai-rui Zhao;Jin-xiu Xu;Guang-ya Wang(Department of the Second Endocrinology,Cangzhou Central Hospital,Cangzhou,Hebei 061001,China)

机构地区：[1]河北省沧州市中心医院内分泌二科,河北沧州061001

出　　处：《中国现代医学杂志》2018年第33期103-106,共4页China Journal of Modern Medicine

摘　　要：目的探讨非诺贝特联合二甲双胍治疗2型糖尿病(T2DM)的疗效。方法选取2014年6月-2016年6月沧州市中心医院治疗的112例T2DM患者,按随机数字表法将其分为对照组和研究组,每组56例。对照组予以二甲双胍治疗,口服二甲双胍0.5 g,2次/d;研究组基于对照组结合非诺贝特治疗,口服非诺贝特0.2 g,1次/d。两组均持续用药3个月。观察并比较两组临床疗效、治疗后血清Nesfatin-1、视黄醇结合蛋白4(RBP4)、脂联素(APN)水平及安全性。结果研究组总有效率高于对照组(87.50%vs 69.64%)(P <0.05);研究组治疗后血清Nesfatin-1、APN水平高于对照组,而RBP4低于对照组(P<0.05);两组不良反应情况比较,差异无统计学意义(P>0.05)。结论非诺贝特联合二甲双胍治疗T2DM能有效改善血糖,其机制可能与有效控制血清Nesfatin-1、RBP4及APN水平有关。Objective To explore the effect of Enofibrate combined with Metformin on type 2 diabetes mellitus.Methods A total of 112 cases of Type 2 diabetes from June 2014 to June 2016 were divided into control group(56 cases)and research group(56 cases)according to the table of random number.The control group was treated with Metformin(0.5 g Bid),the research group was based on control group combined with Eenofibrate(2 g Qd),both groups were treated for 3 months.Clinical outcomes,levels of serum Nesfatin-1,retinol binding protein-4(RBP4)and adiponectin(APN)and safety were observed and compared between the groups.Results Total effective rate of the research group was(87.50%)higher than the control group(69.64%),the difference was statistically significant(P<0.05).After treatment,levels of Nesfatin-1 and serum APN in research group were higher than the control group,while level of RBP4 was lower in research group than the control group,the difference was statistically significant(P<0.05).The adverse reaction of the two groups was not different(P>0.05).Conclusions Fenofibrate combined with Metformin in patients with type 2 diabetes can effectively improve blood glucose and control serum levels of Nesfatin-1,RBP4 and APN.

关 键 词：2型糖尿病 非诺贝特 二甲双胍 NESFATIN-1 视黄醇结合蛋白4 脂联素 

分 类 号：R969.4[医药卫生—药理学]