基于信息熵理论的三生调脂舒丸泛制工艺优选  

Optimization of generic technology for Sanshengtiaozhishu Pill based on information entropy theory

作　　者：张韶湘[1] 邹昱蕾[1] 余晓玲[1] 李绍兴 ZHANG Shaoxiang;ZOU Yulei;YU Xiaoling;LI Shaoxing(Preparation Room,Kunming Municipal Hospital of Traditional Chinese Medicine,Kunming,Yunnan 650011,China)

机构地区：[1]云南省昆明市中医医院制剂室,650011

出　　处：《重庆医学》2018年第33期4263-4265,共3页Chongqing medicine

基　　金：云南省昆明市中药医院院内制剂工程技术研究中心项目(2016-2-A-07993)

摘　　要：目的应用信息熵理论优选三生调脂舒丸的制丸工艺。方法以干燥时间、胶液浓度、滚丸时间和干燥温度为因素,以水分、溶散时限和丸重变异系数为评价指标,进行L9(34)正交试验,计算多指标的信息熵及权重系数,优选泛制工艺参数。结果最佳工艺为:胶液浓度4.50mg/mL,滚丸2.0h后于70℃干燥4.0h。结论基于信息熵理论优选出的制丸工艺参数准确可靠、合理可行,适用于三生调脂舒丸的制丸。Objective To optimize the pelleting technology of Sanshengtiaozhishu Pill by using the information entropy theory.Methods The L9(34)orthogonal test was conducted with the drying time,glue concentration,pill-rolling time and drying temperature as the factors,and moisture,time-limit of dissolution and disintegration and pill weight coefficient of variation as the evaluation indexes.The information entropy and weight coefficient of multi-indexes were calculated to optimize the generic technologic parameters.Results The optimal technology was as follows:the glue solution concentration 4.50 mg/mL,pill-rolling for 2.0 h,and then drying for 4.0 h at 70℃.Conclusion The optimized pelleting technology parameters based on the information entropy theory are accurate,reliable,reasonable and feasible,which are suitable for pelleting of Sanshengtiaozhishu Pill.

关 键 词：工艺学 制药 信息熵 综合评价 三生调脂舒丸 泛制工艺 

分 类 号：R944.9[医药卫生—药剂学]