外泌体miRNA在胰腺癌研究中的进展  

Research progress of exosomal miRNA in pancreatic cancer

作　　者：陈佳 王健 金炜[1] 陈旭东[1] 胡晓波[1] CHEN Jia;WANG Jian;JIN Wei;CHEN Xudong;HU Xiaobo(Department of Clinical Laboratory,Longhua Hospital,Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Shanghai Center for Clinical Laboratory,Shanghai 200126,China)

机构地区：[1]上海中医药大学附属龙华医院检验科,上海200032 [2]上海市临床检验中心,上海200126

出　　处：《检验医学》2018年第11期1049-1052,共4页Laboratory Medicine

摘　　要：外泌体是直径为30～100 nm的囊泡样小体,能通过与靶细胞的细胞膜融合、胞吞作用等方式将其携带的微小RNA(miRNA)、蛋白质等传递至靶细胞中,介导细胞间的信息交流并调控细胞的生理功能。近年研究发现,外泌体miRNA在胰腺癌(PC)的发生、发展及诊断中具有重要作用,有望为PC的诊断和治疗提供新的思路。文章结合国内外研究现状,对外泌体miRNA在PC中的作用进行综述。Exosomes are sorts of small extracellular vesicles ranging approximately from 30 nm to 100 nm in diameter,which can serve as carriers transporting microRNA(miRNA),protein and others to target cells by means of cell membrane fusion and cell swallowing,further mediating cell communication and regulating cell physiological function.In recent years,the related researches have found that exosomal miRNA plays a role in the occurrence,development and clinical diagnosis of pancreatic cancer(PC),which is expected to provide new ideas for the diagnosis and treatment of PC.In this review,the role of exosomal miRNA in PC will be introduced based on domestic and overseas research status.

关 键 词：胰腺癌 外泌体 微小RNA 

分 类 号：R446.1[医药卫生—诊断学]