动物源样品中阿维菌素类药物残留检测方法研究进展  

Research Progress on Detection Methods of Avermectin Residues in Animal Origin Samples

作　　者：李玉立 陈可心 唐塔娅 武英豪 沈建忠[1] 程林丽[1] LI Yuli;CHEN Kexin;TANG Taya;WU Yinghao;SHEN Jianzhong;CHENG Linli(College of Veterinary Medicine,China Agricultural University,Beijing 100193,China)

机构地区：[1]中国农业大学动物医学院,北京100193

出　　处：《中国畜牧兽医》2018年第11期3296-3304,共9页China Animal Husbandry & Veterinary Medicine

基　　金：2015年农业行业标准项目--动物组织中阿维菌素类药物的残留检测高效液相色谱法(修订)(2015091)

摘　　要：寄生虫病是较严重的人畜共患病之一,而阿维菌素类药物是目前畜牧业上防治寄生虫病的主要药物。阿维菌素类药物属于大环内酯类抗生素,抗虫药效强大,但也具有神经毒性和发育毒性,脂溶性强,在动物体内分布广泛且代谢周期长,极易造成动物源食品中药物残留的问题,通过食物链危害人类健康。因此,对动物源样品中的阿维菌素类药物残留量进行检测意义重大。目前,应用于动物源样品中阿维菌素类药物残留分析的方法主要有液相色谱—紫外检测法、液相色谱—荧光检测法、酶联免疫吸附法、液相色谱—串联质谱法等。作者对近年来阿维菌素类药物各种检测方法进行了综述,旨在探究各种方法的优劣,为更精准有效地检测动物源食品中阿维菌素类药物的残留提供参考依据。Currently,parasitic disease is one of the more serious zoonoses,and avermectins are the main drugs to control them in animal husbandry.Avermectins are macrolide antibiotics and all have powerful insect-resistant efficacy.However,they also have neurotoxicity and developmental toxins,and are highly fat-soluble.They are widely distributed in animals and have a long metabolic cycle.They are highly prone to cause drug residues in animal-derived foods and endanger human health through the food chain.It is important to detect the residue of avermectins in animal original samples.At present,the methods for analyzing avermectin residues in animal source samples include liquid chromatography-ultraviolet detection,liquid chromatography-fluorescence detection,enzyme-linked immunosorbent assay,liquid chromatography-tandem mass spectrometry,and so on.Here,the authors reviewed various methods for the detection of avermectins in animal original samples published in recent years,aiming at exploring the advantages and disadvantages of these methods and providing a reasonable basis for the more accurate and effective detection of the residues of avermectins in animal source food.

关 键 词：动物源样品 阿维菌素类药物 最大残留限量 残留分析 

分 类 号：S859.84[农业科学—临床兽医学]