克服ATP结合盒药物转运泵介导的肿瘤多药抗药性的研究进展  

Reversal of ATP Binding Cassette Transporters-mediated Multidrug Resistance in Cancer Cells:A Review

作　　者：符立梧[1] FU Li-wu(Cancer Center,Sun Yat-sen University,Guangzhou 510060,China)

机构地区：[1]中山大学肿瘤防治中心,广东广州510060

出　　处：《中山大学学报（医学版）》2018年第6期801-810,共10页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(81673463);国家自然科学基金重点研发计划项目(2018ZX09711002-003-011)。

摘　　要：多药抗药性(MDR)是肿瘤化疗失败的主要原因。介导MDR的原因十分复杂,其中由ATP结合盒(ABC)转运泵,将抗癌药物泵出细胞外,使抗癌药物在肿瘤细胞中的积累减少,从而产生抗药性是介导MDR最常见的原因。克服MDR是肿瘤化疗领域急需解决的主要问题。本文综述ABC转运泵介导的肿瘤耐药及其逆转研究进展。Multidrug resistance,MDR is main limit for successful cancer chemotherapy.The etiology of MDR is complicated.However,among of them,ATP Binding Cassett(ABC)transporters,such as ABCB1,ABCG2,ABCC1,being capable of transporting anti-cancer drug out of tumor cells,downregulating an intracellular accumulation of anticancer drug and resulting in MDR phenotype,are the most common cause.It is the most urgent to conquer MDR in the field of cancer chemotherapy.Here we summarized the ABC transporters-mediated MDR and its reversal.

关 键 词：ABC药物转运泵 肿瘤化疗 多药抗药性 

分 类 号：R9[医药卫生—药学]