早孕期甲状腺功能状态与妊娠期糖尿病的相关性  

Correlation between Thyroid Function in the First Trimester and Gestational Diabetes Mellitus

作　　者：李萍[1] 林硕[2] 李玲[1] 陈新娟[1] 崔金晖[1] 范建辉[1] LI Ping;LIN Shuo;LI Ling;CHEN Xin-Juan;CUI Jin-Hui;FAN Jian-Hui(Department of Obstetrics and Gynecology,The Third Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510630,China;Department of Endocrine and Metabolic Diseases,The Third Affiliated Hospital,Sun Yat-Sen University,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院产科,广东广州510630 [2]中山大学附属第三医院内分泌与代谢疾病科,广东广州510630

出　　处：《中山大学学报（医学版）》2018年第6期879-883,共5页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省科技计划项目(2017A020215026)

摘　　要：【目的】探讨早孕期甲状腺功能状态与妊娠期糖尿病(GDM)的相关性。【方法】选取2016年6月至2017年6月在我院产检的单胎孕妇2 112例。于妊娠9～13+6周测定游离甲状腺素(FT4)、促甲状腺素(TSH)及甲状腺过氧化物酶抗体(TPOAb);于24～28周行口服糖耐量试验(OGTT),结果异常者为GDM组(224例),正常者为非GDM组(1 888例),分析两组孕妇甲状腺激素水平的差异及利用Spearman秩相关分析甲状腺激素水平与OGTT各时相血糖的相关性。【结果】GDM孕妇与非GDM孕妇早孕期TSH[1.04(0.61-1.61)vs 1.11(0.59-1.77)μU/mL,P=0.292]、FT4[16.22(14.22-18.31)vs 16.62(14.54-18.79)pmol/L,P=0.087]及各甲状腺功能异常的发病率比较差异均无统计学意义(P> 0.05);校正了孕妇年龄、产次及孕前体质量指数后,早孕期TSH和FT4与OGTT各时相血糖无明显的相关性。【结论】早孕期甲状腺功能状态与GDM无明显相关性。【Objective】The present study aimed to evaluate the correlation between thyroid function in the first trimester and gestational diabetes mellitus(GDM).【Methods】A total of 2 112 singleton pregnant women had been recruited from the Third Affiliated Hospital of Sun Yat-Sen University during June 2016 to June 2017.Levels of free thyroxine(FT4),thyroid stimulating hormone(TSH)and thyroid peroxidase antibody(TPOAb)were measured at 9-13+6 gestational weeks.Oral glucose tolerance test(OGTT)was performed at 24-28 gestational weeks and the women were divided into GDM group(n=224)and non-GDM group(n=1 888).The differences of thyroid functions were compared between the two groups.Spearman was used to analyse the correlations between the thyroid hormone levels and the blood glucose levels of OGTT.【Results】There were no statistical differences in TSH[1.04(0.61-1.61)vs 1.11(0.59-1.77)μU/mL,P=0.292]and FT4[16.22(14.22-18.31)vs 16.62(14.54-18.79)pmol/L,P=0.087]between the two groups.The incidences of thyroid dysfunctions were also not different between the two groups(P>0.05).No correlations were found between TSH,FT4 and the blood glucoses of OGTT after adjusting the maternal age,parity and pregestational body mass index.【Conclusion】There was no significant correlation between thyroid function in the first trimester and GDM.

关 键 词：甲状腺功能 妊娠期糖尿病 早孕期 相关性 

分 类 号：R714.7[医药卫生—妇产科学]