基于蛋白及其组装体的金属纳米复合材料构建  

Fabrication of metal nanocomposites based on proteins and their self-assemblies as templates

作　　者：梁淼[1,2] 余涛[1] 高翔 苏荣欣[1] 齐崴[1] 何志敏[1] LIANG Miao;YU Tao;GAO Xiang;SU Rongxin;QI Wei;HE Zhimin(State Key Laboratory of Chemical Engineering,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;School of Food and Biological Engineering,Zhengzhou University of Light Industry,Zhengzhou 450001,Henan,China;State Key Laboratory of Chemical Engineering,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,Zhejiang,China)

机构地区：[1]化学工程联合国家重点实验室,天津大学化工学院,天津300072 [2]郑州轻工业学院食品与生物工程学院,河南郑州450001 [3]化学工程联合国家重点实验室,浙江大学化学工程与生物工程学院,浙江杭州310027

出　　处：《化工学报》2018年第11期4553-4565,共13页CIESC Journal

基　　金：国家自然科学基金项目(51473115);化学工程联合国家重点实验室探索课题项目(SKL-ChE-14T04);天津市自然科学基金重点项目(16JCZDJC37900)。

摘　　要：将蛋白分子及其自组装体作为模板用于功能性金属纳米材料合成吸引了研究者的广泛关注。蛋白质及其自组装体形态结构独特多样,具有特异性分子识别及仿生矿化能力,在纳米材料形成过程中可发挥结构导向及形貌控制作用,以其为模板构建的蛋白-金属纳米复合材料在催化转化、生物传感、医学成像等领域具有广阔的应用前景。本文基于蛋白质及其组装体的结构特征差异,综述了近些年在以蛋白质单亚基结构、蛋白多亚基超组装结构及蛋白三维晶体结构为模板的金属纳米复合材料构建研究方面取得的进展,并对其未来的研究发展方向进行了展望。Fabrication of functional metal nanocomposites by using protein and its self-assemblies as template has aroused the interest of the researchers.Protein and its self-assemblies generally exhibit various morphological structures and possess specific molecular-recognition as well as biomimetic mineralization capabilities.These characteristics make them could play an important role of structural orientation and morphology control during the assisted synthesis of metal nanostructures.And the fabricated protein-metal nanostructures composites exhibit broad prospect of applications in catalytic conversion,biosensing,medical imaging and so on.Based on the differences in structural characteristics of proteins and their assemblies,this review summarizes the recent progress in the construction of metal nanocomposites based on protein single subunits,protein multi-subunit super assembled structures and three-dimensional protein crystals.The direction of research and development is forecasted.Furthermore,the future research direction in this field is prospected.

关 键 词：蛋白质 自组装 蛋白晶体 金属纳米 复合材料 

分 类 号：O635[理学—高分子化学]