石墨烯在骨组织工程中的应用  

Application of graphene in bone tissue engineering

作　　者：张骏[1] 尤奇[1] 熊华章[1] 邹刚[1] 金瑛[1] 葛振 刘毅[1] Zhang Jun;You Qi;Xiong Huazhang;Zou Gang;Jin Ying;Ge Zhen;Liu Yi(First Department of Orthopedics,Affiliated Hospital of Zunyi Medical University,Zunyi Medical University(College),Zunyi 563000,Guizhou Province,China)

机构地区：[1]遵义医学院附属医院骨一科,贵州省遵义市563000

出　　处：《中国组织工程研究》2019年第2期304-309,共6页Chinese Journal of Tissue Engineering Research

基　　金：贵州省科学技术基金资助项目(黔科合LH字[2016]7477号;项目负责人:熊华章;黔科合LH字[2017]7015号;项目负责人:邹刚);遵义医学院附属医院项目[(2016)34号;项目负责人:金瑛]~~

摘　　要：背景:石墨烯具有良好的生物相容性和高机械强度,已在组织工程学中广泛应用。目的:综述石墨烯的一般性质、降解性能、生物相容性及在骨组织工程中的应用。方法:应用计算机检索CNKI数据库、PubMed数据库及Elsevier数据库的2000年1月至2018年4月发表的相关文献,检索词为"石墨烯,石墨烯衍生物,组织工程,骨组织工程;graphene,graphene derivatives,tissue engineering,bone tissue engineering"。通过阅读文题和摘要进行初步筛选,排除与文章主题不相关的文献,根据纳入标准和排除标准,最终纳入65篇文献进行结果分析。结果与结论:(1)石墨烯具有良好的生物相容性、可降解性,细胞毒性较弱,对细胞增殖无明显影响,可作为组织工程支架搭载细胞,使其在上面生长;(2)石墨烯及其衍生物能够促进间充质干细胞的生长和成骨分化,对于修复骨缺损和骨再生有明显的促进作用,能够应用于骨组织工程的研究;(3)石墨烯和其他聚合物、矿物质或金属结合后能够改善其性能,可进一步促进其成骨分化的能力。BACKGROUND:Graphene has good biocompatibility and high mechanical strength,which has been widely used in tissue engineering.OBJECTIVE:To review the general properties,degraded properties,biocompatibility,and application of graphene in bone tissue engineering METHODS:A computer-based search of CNKI,PubMed,and Elsevier was performed for retrieving articles concerning the application of graphene in bone tissue engineering published from January 2000 to April 2018.The keywords were“grapheme,graphene derivatives,tissue engineering,bone tissue engineering”in Chinese and English,respectively.The preliminary screening was carried out by reading titles and abstracts,and according to inclusion and exclusion criteria,65 articles were finally included for result analysis after removal of unrelated articles.RESULTS AND CONCLUSION:(1)Graphene has good biocompatibility,degradability,weak cytotoxicity,and has no obvious effect on cell proliferation.Therefore,graphene can be used as a tissue engineering scaffold to carry cells that can grow on the scaffold surface.(2)Graphene and its derivatives can promote the growth and osteogenic differentiation of mesenchymal stem cells,and have a significant role in the repair of bone defects and bone regeneration.Therefore,they can be applied in bone tissue engineering.(3)Graphene combined with other polymers,minerals or metals can improve their performance,and can further promote the osteogenic differentiation.

关 键 词：石墨烯 石墨烯衍生物 骨组织再生 组织工程 干细胞 成骨分化 综述 骨再生 干细胞 组织工程 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]