银离子敷料治疗糖尿病足溃疡疗效的Meta分析  

Effect of silver dressing on diabetic foot ulcer: a Meta-analysis

作　　者：黄锐娜 黄锐佳 牛彩丽 邱文波 吴小婉[1] 王小俊[3] 王海焦[3] 杨超洁 Huang Ruina;Huang Ruijia;Niu Caili;Qiu Wenbo;Wu Xiaowan;Wang Xiaojun;Wang Haijiao;Yang Chaojie(College of Nursing,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510000,Guangdong Province,China;Department of Reproductive Medicine,the First Affiliated Hospital of Shantou University Medical College,Shantou 515041,Guangdong Province,China;Rehabilitation Nursing Center,the First Affiliated Hospital,Guangzhou University of Traditional Chinese Medicine,Guangzhou 510405,Guangdong Province,China;the First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,Guangdong Province,China)

机构地区：[1]广州中医药大学护理学院,广东省广州市510000 [2]汕头大学医学院第一附属医院生殖医学科,广东省汕头市515041 [3]广州中医药大学第一附属医院康复护理中心,广东省广州市510405 [4]中山大学附属第一医院,广东省广州市510080

出　　处：《中国组织工程研究》2019年第2期323-328,共6页Chinese Journal of Tissue Engineering Research

基　　金：广东省中医药建设专项资金立项资助科研课题(20181083;项目负责人:王海焦)~~

摘　　要：背景:国内外治疗糖尿病足使用的敷料种类有很多种,其中银离子敷料应用广泛,但尚未形成定论。目的:应用Meta分析法评价银离子敷料治疗糖尿病足溃疡的疗效。方法:应用计算机检索PubMed、Embase、Elsevier、中国知网(CNKI)、中国生物医学文献数据库、维普数据库、万方数据库中有关银离子敷料治疗糖尿病足溃疡的随机对照试验,文献发表时间设定为建库至2018年3月,文献质量的评价和资料提取由2名研究员进行,对符合质量标准的研究进行Meta分析。结果与结论:(1)共纳入7篇文献,共642例患者;(2)Meta分析结果显示,银离子敷料组伤口痊愈率明显高于其他敷料组[OR=2.34,95%CI(1.57,3.48),P <0.000 1],上皮形成时间明显早于其他敷料组[MD=-2.22,95%CI(-2.77,-1.66),P <0.000 01],肉芽组织出现时间明显早于其他敷料组[MD=-2.84,95%CI(-3.26,-2.41),P <0.000 01],创面基本愈合时间明显早于其他敷料组[MD=-11.13,95%CI(-19.87,-2.39),P=0.01];(3)结果表明,银离子敷料能够促进糖尿病足溃疡愈合。BACKGROUND:Various kinds of dressings for diabetic foot have been developed,among which,silver dressing has been widely used,but no conclusion has been reached yet.OBJECTIVE:To evaluate the effects of silver dressing in the treatment of diabetic foot ulcers by a Meta-analysis.METHODS:A systematic search of literatures in PubMed,Embase,Elsevier,CNKI,CBM,VIP and WanFang from inception to March 2018 was conducted.The quality of the literatures was appraised and data were extracted by two researchers independently.Meta-analysis was then conducted for the included literatures.RESULTS AND CONCLUSION:A total of 7 randomized controlled trials involving 642 patients were included.The meta-analysis results showed that the wound healing rate of silver dressing group was significantly higher than that of the other dressing groups[odds ratio(OR)=2.34,95%confidence interval(CI)(1.57,3.48),P<0.000 1],epithelial formation time was significantly shorter than that of other dressing groups[mean difference(MD)=-2.22,95%CI(-2.77,-1.66),P<0.000 01],occurrence time of granulation tissue was significantly shorter than that of the other dressing groups[MD=-2.84,95%CI(-3.26,-2.41),P<0.000 01],wound healing time was significantly shorter than that of the other dressing groups[MD=-11.13,95%CI(-19.87,-2.39),P=0.01].Overall,silver dressing can promote the healing of diabetic foot ulcers.

关 键 词：银离子敷料 糖尿病足 随机对照试验 META分析 生物材料 糖尿病足 生物敷料 META分析 组织工程 

分 类 号：R459.9[医药卫生—治疗学] R318[医药卫生—临床医学]