丙酸氯倍米松的分子振动光谱  

The molecular vibrational spectra of clobetasol propionate

作　　者：张倩芝 陈晓红 张卫红 陈建 ZHANG Qianzhi;CHEN Xiaohong;ZHANG Weihong;CHEN Jian(Instrumental Analysis and Research Center,Sun Yat-sen University,Guangzhou 510275,China)

机构地区：[1]中山大学测试中心,广东广州510275

出　　处：《中山大学学报（自然科学版）》2018年第6期119-123,共5页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：国家自然科学基金(21576301;51373205)

摘　　要：利用傅里叶变换红外光谱与傅里叶变换拉曼光谱技术对甾体激素类药丙酸氯倍米松进行分子振动光谱的表征,并结合二阶导数谱进一步提高谱图的分辨率。结果表明结合两种分子光谱的特点能对结构复杂药物的谱图进行了更准确的谱峰归属解析,提供了丙酸氯倍米松完整的分子振动光谱特征,为药物在无损状态下的结构信息表征提供了依据。FT-IR and FT-Raman are applied to characterize the molecular vibrational spectra of Clobetasol Propionate.The second derivative spectra are used to enhance the spectra s resolution.The results show that the spectra s bands of Clobetasol Propionate can be more sufficiently assigned by combining two kinds molecular spectra.The research proves that the structure information of medicine can be obtained under no-destructive state.

关 键 词：傅里叶变换红外光谱 傅里叶变换拉曼光谱 二阶导数谱 分子振动光谱 

分 类 号：O657.33[理学—分析化学]