血清新脂肪因子前神经降压肽与贵州省汉族人群代谢综合征相关  

Association of serum proneurotensin levels with metabolic syndrome in Guizhou Han population

作　　者：宁冬平 许可 朱惠娟 单广良[3] 王定明[4] 平波[5] 余杨文[4] 潘慧 龚凤英 NING Dong-ping;XU Ke;ZHU Hui-juan;SHAN Guang-liang;WANG Ding-ming;PING Bo;YU Yang-wen;PAN Hui;GONG Feng-ying(Graduate School,Hebei North University,Zhangjiakou 075000;Key Laboratory of Endocrinology of National Health Commission,Dept.of Endocrinology,Translation Medicine Centre,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730;Dept.of Epidemiology and Health Statistics,Institute of Basic Medical Sciences,CAMS&PUMC,Beijing 100005;Guizhou Provincial Center for Disease Control and Prevention,Guiyang 550004;Longli Center for Disease Control and Prevention,Longli 551200,China)

机构地区：[1]河北北方学院研究生学院,河北张家口075000 [2]中国医学科学院北京协和医学院北京协和医院内分泌科国家卫生健康委员会内分泌重点实验室协和转化医学中心,北京100730 [3]中国医学科学院基础医学研究所北京协和医学院基础学院流行病与卫生统计学系,北京100005 [4]贵州省疾病预防控制中心,贵州贵阳550004 [5]贵州省龙里县疾病预防控制中心,贵州龙里551200

出　　处：《基础医学与临床》2018年第12期1673-1679,共7页Basic and Clinical Medicine

基　　金：国家"十二五"科技支撑项目(2012BAI37B02);中国医学科学院医学与健康科技创新工程项目(2016-I2M-1-008);国家自然科学基金(81673184;81370898);北京市自然科学基金(7082079;7182130);国家临床重点专科建设项目(WBYZ2011-873)

摘　　要：目的探讨血清新脂肪因子前神经降压肽(PNT)血清水平与代谢综合征指标的相关性。方法在中国贵州省汉族体检人群中,按年龄、性别匹配设立健康对照组(n=70),按照IDF代谢综合征诊断标准筛选非代谢综合征组(n=84)和代谢综合征组(n=158)。用ELISA测定血清PNT水平。结果代谢综合征组人群血清PNT水平较对照组明显增高10. 3%[(57. 54±13. 16) ng/L vs(52. 19±13. 28) ng/L,P<0. 05]。PNT浓度与BMI、脂肪百分比、WHR、TC、TG、DBP、FBG及Cr呈正相关,与年龄呈负相关。TG、FBG、LDL-C和年龄是血清PNT浓度的独立影响因素。将血清PNT水平进行三等分,二元logistic回归分析发现,校正年龄、性别后,代谢综合征组与对照组相比,血清PNT水平最高分位人群患代谢综合征的风险是PNT水平最低分位人群的2. 32倍(95%CI 1. 34～4. 87,P<0. 05)。结论首次发现PNT与代谢综合征多个组分,如肥胖指标、血糖、血脂和血压均呈正相关,与年龄呈负相关。血清PNT水平增高可能是代谢综合征患病的危险因素。Objective To investigate the association of serum proneurotensin(PNT)level with metabolic syndrome(MetS)-related items.Methods A total of 312 Hans from Guizhou province were recruited in the present study and divided into control,non-MetS and MetS groups according to age and gender.Subjects with or without MetS were diagnosed according to IDF diagnostic criteria.Serum PNT levels were measured by an enzyme-linked immunosorbent assay method.Results Serum PNT levels in the MetS group were significantly increased by 10.3%as compared with the controls[(57.54±13.16)ng/L vs(52.19±13.28)ng/L,P<0.05].Serum PNT level as an independent factor was negatively correlated with age,but positively correlated with TG,FBG and LDL-C in all subjects.TG,FBG,LDL-C and age were independent factors for serum PNT levels.According to tertiles of PNT,binary logistic regression analysis between MetS and controls showed that the risk of MetS in subjects with the highest serum PNT levels was 1.32-fold higher than in those with the lowest PNT levels after adjusting for age and gender[odds ratio(OR)=2.32,95%confidence interval(CI)1.34~4.87,P<0.05].Conclusions The serum PNT level is positively correlated with components of MetS and negatively correlated with age as an independent factor.Subjects with high serum PNT level are more susceptible to MetS than those with low PNT level.PNT might be the risk factor of MetS.

关 键 词：前神经降压肽 代谢综合征 脂肪细胞因子 相关性 

分 类 号：R589[医药卫生—内分泌]