两种提取油对胃溃疡小鼠的胃酸分泌水平及胃蛋白酶活性的影响比较  

Comparison of the effects of two kinds of extract oil on gastric acid secretion and pepsin activity in mice with gastric ulcer

作　　者：周志林[1] 梅勇[1] 戴军[1] 杨旭辉[1] 赵志辉[1] ZHOU Zhi-lin;MEI Yong;DAI Jun;YANG Xu-hui;ZHAO Zhi-hui(Dept.of General Surgery,Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430077,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院普通外科,湖北武汉430077

出　　处：《基础医学与临床》2018年第12期1724-1726,共3页Basic and Clinical Medicine

摘　　要：目的对比两种提取油对胃溃疡小鼠胃酸分泌水平及胃蛋白酶活性的影响,为治疗胃溃疡疾病提供实验依据。方法 120只昆明小鼠随机均分为对照组、模型组、黄秋葵种子油和姜油预防组。给药1周后,利用无水乙醇诱导法制备胃溃疡小鼠模型。检测计算各组小鼠胃液总酸度及胃蛋白酶活性。结果模型组小鼠胃液总酸度及胃蛋白酶活性均高于对照组(P<0. 05);黄秋葵种子油组和姜油组小鼠胃液总酸度及胃蛋白酶活性均低于对照组,且黄秋葵种子油组较姜油组低(P<0. 05)。结论黄秋葵种子油和姜油均对无水乙醇诱导型胃溃疡小鼠胃黏膜有保护作用,且同等剂量黄秋葵种子油的保护作用更显著。Objective To compare the effect of two kinds of extract oil on gastric acid secretion and pepsin activity in mice with gastric ulcer and provide experimental basis for the treatment of gastric ulcer disease.Methods One hundred and twenty kunmin mice were randomly divided into control group,model group,okra seed oil and ginger oil prevention group.The gastric ulcer mice model was induced by ethanol,which were then given drugs for one week.The total acidity of gastric juice and pepsin activity in each group were measured and calculated.Results The total acidity and pepsin activity of gastric juice in the model group were higher than that in the blank control group(P<0.05).The total acidity and pepsin activity of gastric juice in okra seed oil group and ginger oil group were lower than that in the control group;The total acidity and pepsin activity of gastric juice in okra seed oil group were lower than that in ginger oil group(P<0.05).Conclusions Okra seed oil and ginger oil have protective effect on gastric ulcer in mice gastric mucosa,and the protective effect of the same dosage of the seed oil of okra is more significant.

关 键 词：黄秋葵种子油 姜油 胃溃疡 胃酸 胃蛋白酶 

分 类 号：R332[医药卫生—人体生理学]