多聚免疫球蛋白受体功能及其表达调节机制  

Function and Regulatory Mechanism of Polymeric Immunoglobulin Receptor in Mammals and Fish

作　　者：绳秀珍 汤茜[1] 唐小千 邢婧 战文斌[1] SHENG Xiu-Zhen;TANG Qian;TANG Xiao-Qian;XING Jing;ZHAN Wen-Bin(The Key Laboratory of Mariculture(Ocean University of China),Ministry of Education,Qingdao 266003,China)

机构地区：[1]海水养殖教育部重点实验室(中国海洋大学),山东青岛266003

出　　处：《中国海洋大学学报（自然科学版）》2018年第A02期1-8,共8页Periodical of Ocean University of China

基　　金：国家自然科学基金项目(31472295;31730101;31672685);山东省泰山学者特聘专家项目资助~~

摘　　要：黏膜免疫是机体免疫系统的重要组成部分,鱼类的皮肤、鳃、肠等黏膜免疫相关组织及黏液是机体免疫保护的第一道防线。分泌型抗体(SIgs)是黏膜免疫的主要组成成分,经多聚免疫球蛋白受体(pIgR)介导的转胞吞作用穿过上皮细胞转运至黏膜表面发挥免疫防御功能。目前,对哺乳动物pIgR介导SIgs的转运过程,pIgR功能及调节因子,以及细胞因子、微生物、激素等调节pIgR表达的信号通路已研究得较透彻,而鱼类pIgR研究多集中于基因克隆、组织差异表达等,对pIgR表达调节方面的研究较少。本文综述了哺乳动物pIgR的功能、调节机制以及硬骨鱼类pIgR的相关研究进展,为探究鱼类pIgR表达的调节机制提供参考资料。The mucosa-associated tissues and mucus of teleost form the first defense against pathogens.Mucosal immune system plays a key role in fish immune response and protection.The secretory immunoglobulins(SIgs)are the main players in the mucosal defense,which are transported to the mucosal surface via transcytosis across the epithelium by the polymeric immunoglobulin receptor(pIgR).In mammals,comprehensive studies on pIgR-mediated SIgs transport,pIgR function in mucosal defense,regulatory factors,as well as various cytokines,microbes and hormones up-regulating the pIgR expression through multiple signaling pathways,have been performed;however few studies on pIgR expression regulation are performed in fish although the cloning and tissue expression analysis of many genes have been carried out.This review described the recent progresses in pIgR biological function,expression regulation,and regulatory mechanism in mammals and teleost aiming to provide a basis for further studies on the expression regulatory mechanism of pIgR in fish.

关 键 词：哺乳动物 鱼类 多聚免疫球蛋白受体(PIgR) 功能 调节作用 分泌型抗体 黏膜免疫 

分 类 号：S917[农业科学—水产科学]