左旋咪唑与槐杞黄颗粒在儿童激素敏感型肾病综合征中的应用价值比较  

Comparison of the value of levamisole and Huaiqihuang granules in children with hormone-sensitive nephrotic syndrome

作　　者：黄忠[1] 冯杰[1] 杨振中 Huang Zhong;Feng Jie;Yang Zhenzhong(Pediatric Department,Guizhou Provincial People’s Hospital,Guiyang 550002,China)

机构地区：[1]贵州省人民医院儿科,贵州贵阳550002

出　　处：《河南医学研究》2018年第21期3871-3873,共3页Henan Medical Research

摘　　要：目的比较左旋咪唑与槐杞黄颗粒辅助治疗激素敏感型原发性肾病综合征(PNS)患儿对患儿感染和复发情况的影响。方法回顾性分析2015年1月至2018年1月于贵州省人民医院儿科就诊的76例激素敏感型PNS患儿的临床资料,根据患儿用药分为左旋咪唑组(36例)和槐杞黄颗粒组(40例)。两组患儿均接受糖皮质激素中长程疗法治疗,左旋咪唑组接受左旋咪唑治疗,槐杞黄颗粒组接受槐杞黄颗粒治疗。随访6个月,统计两组患儿感染、复发情况。结果左旋咪唑组感染发生率为50. 00%(18/36),槐杞黄颗粒组为75. 00%(30/40),左旋咪唑组感染发生率低于槐杞黄颗粒组,差异有统计学意义(P <0. 05)。随访6个月,左旋咪唑组平均感染例次为(0. 86±1. 05)例次,槐杞黄颗粒组平均感染例次为(2. 13±1. 74)例次,左旋咪唑组感染例次少于槐杞黄颗粒组,差异有统计学意义(P <0. 05)。左旋咪唑组复发率为41. 67%(15/36),槐杞黄颗粒组复发率为72. 50%(29/40),左旋咪唑组复发率低于槐杞黄颗粒组,差异有统计学意义(P <0. 05)。结论左旋咪唑可有效减少激素敏感型PNS患儿的感染和病情复发,其作用强于槐杞黄颗粒。Objective To compare the effects of levamisole and Huaiqihuang granules on the infection and recurrence of children with hormone-sensitive primary nephrotic syndrome(PNS).Methods The clinical data of 76 patients with steroid-sensitive PNS who were admitted to the Pediatric Department of Guizhou Provincial People’s Hospital from January of 2015 to January of 2018 was retrospectively analyzed.According to the children's medication,they were divided into levamisole group(36 cases)and Huaiqihuang granule group(40 cases).Both groups received long-term therapy with glucocorticoids.children in levamisole group was treated with levamisole,and children in Huaiqihuang granule group were treated with Huaiqihuang granules.After 6 months of follow-up,the infection and recurrence of the two groups were counted.Results The incidence of infection in levamisole group was 50.00%(18/36),and that in Huaiqihuang granule group was 75.00%(30/40).The incidence of infection in levamisole group was lower than that in Huaiqihuang granule group,and the difference was statistically significant(P<0.05).During the follow-up of 6 months,the average cases of infection in levamisole group were(0.86±1.05)case-times,and that in Huaiqihuang granule group were(2.13±1.74)case-times.The average case-times of infection in levamisole group were less than that in Huaiqihuang granule group,the difference was statistically significant(P<0.05).The recurrence rate of levamisole group was 41.67%(15/36),and that of Huaiqihuang granule group was 72.50%(29/40).Recurrence rate of levamisole group was lower than that of Huaiqihuang granule group,the difference was statistically significant(P<0.05).Conclusion Levamisole can effectively reduce the infection and recurrence of children with hormone-sensitive PNS,and its effect is stronger than Huaiqihuang granule.

关 键 词：原发性肾病综合征 左旋咪唑 槐杞黄颗粒 免疫调节 感染 复发 

分 类 号：R692[医药卫生—泌尿科学]