血磷与代谢综合征各组分的关系分析  

Relationship between serum phosphorus level and components of metabolic syndrome

作　　者：李楠[1] 肖海英[2] 李春霖[1] 李剑[1] 卢艳慧[1] 闫双通[1] 刘敏燕[1] 龚燕平[1] 成晓玲[1] Li Nan;Xiao Haiying;Li Chunlin;Li Jian;Lu Yanhui;Yan Shuangtong;Liu Minyan;Gong Yanping;Cheng Xiaoling(Department of Endocrinology,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院南楼内分泌科,北京100853 [2]解放军总医院海南分院内分泌科

出　　处：《中华老年心脑血管病杂志》2018年第11期1134-1137,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：解放军总医院科技创新苗圃基金(17KMM17)

摘　　要：目的探讨男性血磷水平与代谢综合征(metabolic syndrome,MS)及其各组分的关系。方法收集2015年5~6月解放军总医院常规年度体检的男性体检者477例,根据诊断分为MS组61例及非MS组416例。又根据患者血磷三分位由低到高等分,T1(0.89~1.07mmol/L)、T2(1.08~1.19mmol/L)、T3(1.20~1.60mmol/L),每分位159例。分析血磷与MS及其各组分的相互关系。结果 MS组年龄、体质量指数、心率、收缩压、舒张压、空腹血糖、餐后2h血糖、TC、TG、LDL-C、腰围明显高于非MS组,血磷、25羟维生素D及HDL-C明显低于非MS组,差异有统计学意义(P<0.05,P<0.01)。相关性分析显示,校正前和校正后血磷与空腹血糖均呈负相关(r=-0.196,P=0.000;r=-0.114,P=0.013)。随血磷水平下降,T3、T2、T1的MS患病率升高(17.6%vs 11.3%vs9.4%,P=0.033),腰围、空腹血糖和餐后2h血糖明显升高,差异有统计学意义(P<0.05,P<0.01)。未校正年龄和体质量指数前,MS和高血糖患病率随血磷降低有明显升高。校正年龄和体质量指数后,仅有血糖的趋势存在,T1较T3的OR值为2.563(95%CI:1.061~6.692,P=0.036)。结论较低的血磷水平与男性代谢综合征,尤其是高血糖的发病有关。Objective To study the relationship between serum phosphorus level and components of metabolic syndrome(MS)in male patients.Methods Four hundred and seventy-seven male patients who underwent physical examination in PLA General Hospital from May to June of 2015 were divided into MS group(n=61)and MS-free group(n=416).The patients were further divided into T1(0.89-1.07 mmol/L)group(n=159),T2(1.08-1.19 mmol/L)group(n=159)and T3(1.20-1.60 mmol/L)group(n=159)according to their phosphorus level.The relationship between serum phosphorus level and components of MS was analyzed.Results The age was significantly older,the body mass index(BMI),heart rate,SBP,DBP,postprandial 2-h FPG,and serum TC,TG,LDL-C levels were significantly higher,the waist circumference was significantly longer while the serum phosphorus,25-hydroxy vitamin D and HDL-C levels were significantly lower in MS group than in MS-free group(P<0.05,P<0.01).Correlation analysis showed that serum phosphorus level was negatively related with FPG befroe and after adjustment of age and BMI(r=-0.196,P=0.000;r=-0.114,P=0.013).The incidence of MS increased with the decrease of serum phosphorus level in T3,T2,T1 groups(17.6% vs 11.3% vs 9.4%,P=0.033).The waist circumference was significantly longer,the FPG and postprandial 2-h BG levels were significantly higher in T3,T2,T1 groups(P<0.05,P<0.01).The incidence of MS was higher while the serum phosphorus level was lower before adjustment of age and BMI.The OR value was2.563 in T1 group after adjustment of age and BMI(95%CI:1.061-6.692,P=0.036).Conclusion Low serum phosphorus level is closely related with MS,especially with hyperglycemia in male patients.

关 键 词：肥胖症 高血糖症 血脂异常 人体质量指数 磷 

分 类 号：R589[医药卫生—内分泌]