异甘草酸镁与甘利欣治疗病毒性肝炎的疗效对比分析  

Comparative analysis of the efficacy of magnesium isoglycyrrhizinate and Ganlixin in the treatment of viral hepatitis

作　　者：郑海鹏[1] 陈彬彬[1] ZHENG Hai-peng;CHEN Bin-bin(Department Two of Infection,Guangzhou Eighth People’s Hospital,Guangzhou 510060,China)

机构地区：[1]广州市第八人民医院感染二科,510060

出　　处：《中国现代药物应用》2018年第23期10-11,共2页Chinese Journal of Modern Drug Application

摘　　要：目的对比异甘草酸镁与甘草酸二铵胶囊(甘利欣)治疗病毒性肝炎的疗效。方法 90例病毒性肝炎患者,根据随机数字表法分为观察组与对照组,各45例。对照组给予甘利欣治疗观察组则给予异甘草酸镁治疗。比较两组治疗效果、用药安全性、肝功能指标正常时间、病毒转阴时间以及治疗前后肝功能指标水平。结果观察组治疗总有效率为97.78%,明显高于对照组的68.89%,差异具有统计学意义(P<0.05)。治疗前,两组总胆红素(TBIL)、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)水平比较差异无统计学意义(P>0.05);治疗后,观察组TBIL、AST、ALT水平优于对照组,差异具有统计学意义(P<0.05)。观察组肝功能指标正常时间、病毒转阴时间分别为(3.43±1.41)周、(3.04±0.21),均明显短于对照组的(4.42±2.12)、(4.21±1.55)周,差异具有统计学意义(P<0.05)。观察组不良反应发生率4.44%与对照组的6.67%比较,差异无统计学意义(P>0.05)。结论异甘草酸镁治疗病毒性肝炎的疗效确切,可有效改善肝功能,促进病毒转阴,提高用药安全性,值得推广应用。Objective To compare the efficacy of magnesium isoglycyrrhizinate and diammonium glycyrrhizinate capsule(Ganlixin)in the treatment of viral hepatitis.Methods A total of 90 viral hepatitis patients were divided by random number table into observation group and control group,with 45 cases in each group.The control group was treated with Ganlixin,and the observation group was treated with magnesium isoglycyrrhizinate.Comparison were made on treatment effect,drug safety,liver function index normal time,virus negative time,and liver function index level before and after treatment between the two groups.Results The observation group had obviously higher total treatment effective rate as 97.78%than 68.89%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in total bilirubin(TBIL),aspartate aminotransferase(AST)and alanine aminotransferase(ALT)level(P>0.05).After treatment,the observation group had better TBIL,AST and ALT level than the control group,and the difference was statistically significant(P<0.05).The observation group had liver function index normal time as(3.43±1.41)weeks,virus negative time as(3.04±0.21)weeks,which were obviously shorter than(4.42±2.12)and(4.21±1.55)weeks in the control group,and their difference was statistically significant(P<0.05).The observation group had no statistically significant difference in incidence of adverse reactions as 4.44%,comparing with 6.67%in the control group(P>0.05).Conclusion Magnesium isoglycyrrhizinate provides affirmative efficacy in treating viral hepatitis,and it can effectively improve liver function,promote virus negative-conversion,and improve the drug safety.So it is worthy of promotion and application.

关 键 词：异甘草酸镁 甘草酸二铵胶囊 病毒性肝炎 疗效对比 

分 类 号：R512.6[医药卫生—内科学]