基于活塞挤出式3D打印制备PLA/n-HA生物支架  

Preparation of PLA/n-HA Bio-scaffold Based on Piston Extrusion 3D Printing

作　　者：王波群[1,2] 揭晓华[1] 胡晓岳[2] Wang Boqun;Jie Xiaohua;Hu Xiaoyue(School of Materials and Energy,Guangdong University of Technology,Guangzhou 510006,China;School of Advanced Manufacturing Technology,Guangdong Jidian Polytechnic,Guangzhou 510515,China)

机构地区：[1]广东工业大学材料与能源学院,广州510006 [2]广东机电职业技术学院先进制造技术学院,广州510515

出　　处：《工程塑料应用》2018年第12期79-83,共5页Engineering Plastics Application

基　　金：2017年广东省教育厅青年创新人才类项目(2017GkQNCX011)

摘　　要：以聚乳酸(PLA)、纳米羟基磷灰石(n-HA)为主要原料,先通过偶联剂KH550对n-HA进行表面改性,采用熔融共混法制备n-HA质量分数分别为10%,20%,30%,40%的PLA/n-HA复合材料,并用活塞挤出式3D打印技术制备生物支架,通过调整速度、温度等工艺参数,实现生物支架的孔径、孔隙率、亲疏水性的调控。采用扫描电子显微镜、白光干涉仪分析支架的微观形貌,并通过压缩试验测试了力学性能。结果表明,随着n-HA含量的增加,支架表面形貌变得粗糙,成型难度增大,孔隙率不断减少;压缩强度先上升后下降;材料呈现从纯PLA的疏水到n-HA含量10%时的亲水,再到n-HA含量40%时的疏水。Polylactic acid(PLA)/nano-hydroxyapatite(n-HA)composites were prepared by melt blending with PLA and n-HA as the main raw materials,the surface of n-HA was treated by coupling agent KH550 and n-HA weight percentage was 10%,20%,30%,40%respectively.The bio-scaffolds were prepared by piston extrusion 3D printing technology,and the parameters such as speed and temperature were adjusted to realize the control of pore size,porosity and hydrophobicity of the bio-scaffolds.The three-dimensional morphology of the material surface was observed by SEM,white light scanning interferometry and the mechanical properties were tested.The results show that with the increase of n-HA content,the surface morphology of the scaffold becomes rough,the forming difficulty increases,the porosity decreases,and the compression strength increases first and then decreases.The hydrophilic tendency of the materials from pure PLA to 10%content of n-HA is increased,and then tutn to the hydrophobicity at 40%content of n-HA.

关 键 词：聚乳酸 羟基磷灰石 活塞式3D打印 生物支架 

分 类 号：TQ320.662[化学工程—合成树脂塑料工业]