子宫内膜息肉术后患者行冻融周期囊胚移植临床结局分析  

Clinical outcome analysis of freeze-thaw cycle blastocyst transfer in patients with endometrial polyps

作　　者：王超[1,2,3] 邢琼 向卉芬[1,2,3] 徐祖滢 曹云霞[1,2,3] Wang Chao;Xing Qiong;Xiang Huifen;XU Zuying;CAO Yunxia(Reproductive Medicine Center,Dept of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022;Anhui Province Key Laboratory of Reproductive Health and Genetics,Hefei 230022;Biopreservation and Artificial Organs,Anhui Provincial Engineering Research Center,Anhui Medical University,Hefei 230022)

机构地区：[1]安徽医科大学第一附属医院妇产科生殖医学中心,合肥230022 [2]安徽医科大学生殖健康与遗传安徽省重点实验室,合肥230022 [3]安徽省生命资源保存与人工器官工程技术研究中心,合肥230022

出　　处：《安徽医科大学学报》2018年第12期1907-1910,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金项目(编号:1708085QH201);安徽省公益性研究联动计划项目(编号:1704f0804022)

摘　　要：目的分析曾行宫腔镜下子宫内膜息肉切除术患者行冻融周期囊胚移植的临床结局,并比较不同内膜准备方案对临床结局的影响。方法回顾性分析行复苏周期囊胚移植共898个周期的临床资料。具有宫腔镜息肉切除病史者(息肉组)共405个周期,无此病史者(对照组)共493个周期。息肉组根据内膜准备方案分为自然周期亚组(n=201)及激素替代周期亚组(n=204)。分析各组一般资料及临床结局。结果息肉组与对照组比较,息肉组中自然周期亚组与激素替代周期亚组比较,其年龄、不孕年限、基础FSH、BMI、移植胚胎数及生化妊娠率、临床妊娠率、胚胎种植率、流产率、活产率、异位妊娠率差异均无统计学意义。息肉组患者移植日内膜显著厚于对照组,息肉组中自然周期亚组内膜显著厚于激素替代周期亚组。结论不孕症患者行冻融周期囊胚移植,有息肉切除病史者移植日内膜可能会厚于正常者,但并不影响其移植结局,且息肉切除病史的存在亦不影响对内膜准备方案的选择。Objective To analyze clinical outcomes of frozen embryo transfer cycles with history of hysteroscope polypectomy and the influences of different endometrial preparation methods on their outcomes.Methods 898 frozen embryo transfer cycles in our center were retrospectively analyzed.405 cycles(polyps group)had history of hysteroscope polypectomy and 493 cycles(control group)had no such history.Polyps group were divided into natural cycle subgroup(n=201)and hormone replacement therapy subgroup(n=204)according to their endometrial preparation methods.The basic characters and clinical outcomes in different groups were analyzed.Results Items of ages,infertility duration,basic FSH,embryo transfer numbers and chemical pregnancy rate,clinical pregnancy rate,embryo implantation rate,miscarriage rate,live birth rate,ectopic pregnancy rate showed no significant difference in the comparisons of polyps group between control group and the comparisons of 2 subgroups.Endometrium was significantly thicker in polyps group than control group on transplantation day and it was thicker in natural cycle subgroup than hormone replacement therapy subgroup.Conclusion For frozen embryo transfer cycles,endometrium may be thicker on transplantation day in those with the history of polypectomy but it does not affect the clinical outcomes and the existence of the history of polypectomy does not affect the choice of endometrial preparation methods.

关 键 词：息肉 宫腔镜 复苏周期 自然周期 激素替代周期 

分 类 号：R714.8[医药卫生—妇产科学]