混合光传输模型在多光谱契伦科夫荧光断层成像前向问题中的应用  

Application of Hybrid Light Transport Model in Forward Problems of Multispectral Cerenkov Luminescence Tomography

作　　者：任青云 侯榆青[1] 贺小伟[1] 王琳[1] 易黄建[1] 何雪磊 REN Qing-yun;HOU Yu-qing;HE Xiao-wei;WANG Lin;YI Huang-jian;HE Xue-lei(Key Laboratory for Radiomics&Intelligent Sense of Xi′an,Northwest University,Xi′an 710127,China)

机构地区：[1]西北大学西安市影像组学与智能感知重点实验室,西安710127

出　　处：《光子学报》2018年第11期228-239,共12页Acta Photonica Sinica

基　　金：国家自然科学基金(Nos.11571012;61640418;61601363;61601364);陕西省教育厅服务地方专项计划项目(No.17JF027)资助~~

摘　　要：契伦科夫荧光的宽谱特性带来的组织光学特性差异导致传统的光传输模型的简化球谐函数近似和扩散方程无法兼顾准确度和效率,为了解决该问题,采用基于自适应混合简化球谐波近似-扩散方程的光传输模型作为多光谱契伦科夫荧光断层成像的前向模型.该模型利用组织光学特性参数自适应地选择合适的方程描述光在生物组织中的传输,充分发挥传统光传输模型各自的优势,以提供准确性和效率之间的平衡.通过简单规则几何实验和数字鼠实验验证所提出模型的准确性和效率.实验结果表明,与简化球谐近似模型相比,所提模型具有相同的准确度和更少的计算时间,与扩散方程模型相比具有更高的准确度,与简化球谐波近似-扩散方程的简单组合模型相比具有更好的自适应能力,适合作为多光谱契伦科夫荧光断层成像的光传输模型.As the wide spectrum range of Cerenkov luminescence light leads to an extremely diverse optical properties of tissues,the simplified spherical harmonics approximation or diffusion equation based imaging model cannot balance accuracy with effectiveness.The adaptive hybrid simplified spherical harmonics with diffusion equation model is applied as a forward model for multispectral Cerenkov fluorescence tomography.To provide the perfect balance between accuracy and efficiency,based on the tissues optical properties,the proposed model can adaptively select an approximate equation to describe the Cerenkov luminescence light propagation,and give full play to the advantages of traditional model.The accuracy and efficiency of the proposed model are validated with both regular geometries and digital mouse model based simulations.Corresponding results reveal that a comparable accuracy and much less computation time are achieved compared with the simplified spherical harmonics model,a much better accuracy compared with the diffusion equation as well as better adaptability than simple combined models of simplified spherical harmonics and diffusion equation.The adaptive hybrid simplified spherical harmonics with diffusion equation model model is best suited as an optical transmission model for multispectral Cerenkov fluorescence tomography.

关 键 词：契伦科夫荧光断层成像 混合光传输模型 多光谱策略 组织光学 自适应 

分 类 号：TP391[自动化与计算机技术—计算机应用技术] Q632[自动化与计算机技术—计算机科学与技术]