ICU脓毒症患者血清降钙素原浓度与病原学类型的关系  

Relation of serum procalcitonin concentration with pathogen type in ICU patients with sepsis

作　　者：覃剑 朱继金[2] 杨宇宁[2] 李雄辉[3] 韦文财 闵利[5] 黄华丽 QIN Jian;ZHU Ji-jin;YANG Yu-ning;LI Xiong-hui;WEI Wen-cai;MIN Li;HUANG Hua-li(ICU,Liuzhou Worker's Hospital,Liuzhou 545005,China;Department of Emergency,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Emergency,the181th Hospital of the Chinese People's Liberation Army,Guilin541002,China;Department of Cardiology,Liuzhou Worker's Hospital,Liuzhou 545005,China;ICU,Taihe Hospital of Shiyan City,Shiyan 442000,China;Graduate School,Guangxi Medical University,Nanning 530021 ,China)

机构地区：[1]广西柳州市工人医院重症医学,柳州市545005 [2]广西医科大学第一附属医院急诊科,南宁市530021 [3]中国人民解放军第181医院急诊科,广西桂林市541002 [4]广西柳州市工人医院心内科,柳州市545005 [5]湖北省十堰市太和医院ICU,十堰市442000 [6]广西医科大学研究生院,南宁市530021

出　　处：《广西医学》2018年第21期2521-2523,共3页Guangxi Medical Journal

基　　金：广西自然科学基金(2015JJAA40502);广西急诊与医学救援人才小高地、广西高校急诊医学重点实验室开放课题(GXJZ201417);广西医药卫生科研课题(Z20170886);广西柳州市临床重点专科建设项目(柳卫医[2016]16号)

摘　　要：目的探讨ICU脓毒症患者血清降钙素原(PCT)浓度与病原学类型的关系。方法回顾性分析216例ICU脓毒症患者的临床资料,入院时检测PCT浓度,同时行体液或分泌物病原体培养,比较不同类型致病菌感染病例的PCT阳性率。结果 216例患者共行804份标本培养,符合致病菌标准共253份(31. 46%),其中革兰阴性致病菌、革兰阳性致病菌、真菌感染各192例、28例、33例。革兰阴性致病菌感染患者的PCT阳性率高于革兰阳性致病菌及真菌致病菌感染患者(均P <0. 05)。结论在ICU中,血清PCT阳性常见于革兰阴性致病菌感染病例,这对脓毒症患者的抗生素决策有一定的参考价值。Objective To investigate the relation of serum procalcitonin(PCT)concentration with pathogen type in ICU patients with sepsis.Methods The clinical data of216septic patients in ICU were retrospectively analyzed.The PCT concentration was detected on admission,meanwhile,the pathogen culture of body fluids or secretions was conducted.The positive rate of PCT was compared among the cases infected by different pathogens.Results A total of804specimens from216patients were collected for culture,and pathogenic bacteria or fungi were found in253specimens(31.46%)including192specimens with Gram-negative pathogenic bacteria,28specimens with Gram-positive pathogenic bacteria and33specimen with fungal infection.The PCT positive rate of the patients infected by Gram-negative pathogenic bacteria was higher than that of the patients infected by Gram-positive pathogenic bacteria or fungi(all P<0.05).Conclusion Positive serum PCT is common in the cases infected by Gram-negative pathogenic bacteria in ICU,which provides a certain reference value for antibiotic decision-making in the patients with sepsis.

关 键 词：脓毒症 降钙素原 病原学 重症监护室 

分 类 号：R631[医药卫生—外科学]