TK1、TPOAb和TgAb对甲状腺结节良恶性的诊断价值  

Value of TK1,TPOAb and TgAb in differential diagnosis of benign and malignant thyroid nodules

作　　者：程田[1] 唐振林[1] CHENG Tian;TANG Zhenlin(Department of nuclear medicine,Sichuan Academy of Medical Sciences&Sichuan Provincial People's hospital,Chengdu 610072,China)

机构地区：[1]四川省医学科学院.四川省人民医院核医学科,成都610072

出　　处：《实用医学杂志》2018年第22期3764-3766,共3页The Journal of Practical Medicine

摘　　要：目的探讨血清胸苷激酶1(TK1)、甲状腺过氧化物酶抗体(TPOAb)和甲状腺球蛋白抗体(TgAb)的检测在鉴别甲状腺结节良恶性中的价值。方法选取132例甲状腺恶性结节患者、144例甲状腺良性结节患者以及50例健康者。检测血清TK1、TPOAb及TgAb水平,比较在各组的差异,通过Logistic回归分析和ROC曲线评价三者在鉴别甲状腺结节良恶性中的价值。结果甲状腺恶性结节组TK1、TPOAb和TgAb水平高于良性结节组和健康对照组(P <0.05)。单项检测TK1、TPOAb和TgAb的Cut-off值分别为2.65 pmol/L、28.63 IU/mL和96.12 IU/mL;TK1的特异性、诊断符合率以及曲线下面积(AUC)高于TPOAb和TgAb(P <0.05)。联检阳性预期值Y的Cut-off值为0.683,在灵敏度、特异性、诊断符合率和AUC上均高于各单项(P <0.05)。结论单项TK1检测在鉴别甲状腺结节良恶性上优于TPOAb和TgAb;三者联检可提高灵敏度、特异性以及准确性。Objective To investigate the value of the detection of serum thymidine kinase 1(TK1),thy-roid peroxidase antibody(TPOAb)and thyroglobulin antibody(TgAb)in the differential diagnosis of benign and malignant thyroid nodules.Methods The serum levels of TK1,TPOAb and TgAb were detected in 132 cases of malignant thyroid nodules,144 cases of benign thyroid nodules and 50 cases of normal controls respectively.The levels of TK1,TPOAb and TgAb in each group were compared and evaluated.Logistic regression and ROC curve were adopted to analyze and present the independent association.Results TK1,TPOAb and TgAb levels in patients with malignant thyroid nodules were higher than in those with benign nodules and in healthy controls(P<0.05).ROC showed that the cut-off values of TK1,TPOAb and TgAb were 2.65 pmol/L,28.63 IU/mL and 96.12 IU/mL respectively.The specificity,diagnostic accordance rate and AUC of TK1 were higher than those of TPOAb and TgAb(P<0.05).The cut-off value of Y in the regression equation was 0.683.The sensitivity,speci-ficity,diagnostic accordance rate and AUC of Y were higher than those of TK1,TPOAb and TgAb(P<0.05).Conclusions TK1 was indicative than TPOAb and TgAb in the differential diagnosis of benign and malignant thy-roid nodules.The combined detection of TK1,TPOAb and TgAb can significantly improve the sensitivity,specificity and accuracy of diagnosis,and as such,the combined detection can assist the differentiation of benign and malig-nant thyroid nodules.

关 键 词：胸苷激酶1 甲状腺过氧化物酶抗体 甲状腺球蛋白抗体 甲状腺结节 良恶性 

分 类 号：R581[医药卫生—内分泌]