新活素治疗慢性肺源性心脏病急性加重期的疗效及对5-羟色胺水平的影响  

Efficacy of neovasin in treatment of acute exacerbation of chronic pulmonary heart disease and its effect on serotonin and peptide levels

作　　者：刘雪莲 刘艳洁 白洁[1] 李敬[1] 扈晓霞[1] 郑群[1] LIU Xuelian;LIU Yanjie;BAI Jie;LI Jing;HU Xiaoxia;ZHENG Qun(Department of Cardiology,Harrison International Peace Hospital,Hengshui 053000,China)

机构地区：[1]哈励逊国际和平医院心内科,河北衡水053000

出　　处：《实用医学杂志》2018年第22期3779-3782,共4页The Journal of Practical Medicine

摘　　要：目的研究新活素治疗慢性肺源性心脏病急性加重期患者的临床疗效及对5-羟色胺水平的影响。方法选择2015年1月至2018年1月慢性肺源性心脏病急性加重期患者146例,随机分为治疗组与对照组。对照组给予氧疗、原发病治疗、强心、利尿等,治疗组在常规治疗基础上加用新活素持续静脉泵入。两组疗程为7 d。观察两组患者的临床疗效及6分钟步行距离(6-MWT);治疗前后肺动脉收缩压(PASP)、肺动脉平均压(MPAP)、肺功能指标(TLC、FVC、FEV1/FVC);检测治疗前后NT-proBNP、血管生成素-Ⅱ(Ang-Ⅱ)、和肽素、5-羟色胺(5-HT)水平。结果治疗组的总有效率明显高于对照组,差异有统计学意义。治疗前,两组患者PASP、MPAP、TLC、FVC、FEV1/FVC、NT-proBNP、Ang-Ⅱ、和肽素、5-HT及6-MWT均无统计学意义(P> 0.05)。治疗后,治疗组与对照组PASP、MPAP、肺功能指标、NT-proBNP、Ang-Ⅱ、和肽素、5-HT及6-MWT均得到不同程度的改善(P <0.05);而治疗组改善程度均较对照组更加显著(P <0.05)。相关分析显示:CPHD病情程度与血浆和肽素、5-HT水平呈正相关关系,即CPHD患者病情越重,血浆和肽素、5-HT水平越高。结论新活素能有效降低5-羟色胺、和肽素水平,降低肺动脉高压,迅速缓解慢性肺源性心脏病急性加重期患者的临床状况。Objective To study the clinical efficacy of neovasin in the treatment of patients with acute exacerbation of chronic pulmonary heart disease and its effect on the levels of serotonin and peptide.Methods A total of 146 patients with chronic pulmonary heart disease(CPHD)from January 2015 to January 2018 in our hospital were randomly divided into treatment group and control group.The control group was treated with oxygen therapy,primary disease therapy,cardioversion and diuretic therapy,and the treatment group with continuous intravenous infusion of neovasin on the basis of routine treatment.The course of treatment was 7 days.The clinical efficacy and 6-minute walking distance of the 2 groups were observed;the pulmonary arterial systolic pressure(PASP),mean pulmonary artery pressure(MPAPP),pulmonary function index(TLCFV C)FEV1/FVC,and the levels of NT-proBNPP,angiopoietinⅡAng-Ⅱ,and peptide 5-hydroxytryptamine 5-HT before and after the treatment were observed.Results The total effective rate in the treatment group was significantly higher than that in the control group,and the difference was statistically significant.Before the treatment,there was no significant difference between the 2 groups(P>0.05)in terms of FEV1/FVCV1/FVCU NT-proBNP Ang-Ⅱ,and the levels of peptide 5-HT and 6-MWT.After the treatment,the pulmonary function indexes of PASP MPAPand NT-proBNP Ang-Ⅱ,peptide 5-HT and 6-MWT were improved in different degrees(P<0.05),and the improvement of treatment group was more significant than that of control group(P<0.05).The correlation analysis showed that there was a positive correlation between the degree of CPHD and the level of plasma and peptide 5-HT(P<0.01).Conclusion Neoactin can effectively reduce serotonin,peptide levels,and pulmonary hypertension,and rapidly improvethe conditionof patients with acute exacerbation of CPHD.

关 键 词：新活素 慢性肺源性心脏病 5-羟色胺 和肽素 

分 类 号：R541.5[医药卫生—心血管疾病]