甲亢合并肺部感染患者血清抗炎与促炎介质的表达研究  

Study on the expression of serum anti-inflammatory mediator and pro-inflammatory mediator of patients with hyperthyroidism complicated with pulmonary infection

作　　者：李杰玉[1] 林玉玲[1] 刘琳[1] 籍胤玺[1] 金文波[1] LI Jieyu;LIN Yuling;LIU Lin;JI Yinxi;JIN Wenbo(Department of Endocrinology,Nanyang Central Hospital,Nanyang 473000,Henan,China)

机构地区：[1]南阳市中心医院内分泌科,河南南阳473000

出　　处：《实验与检验医学》2018年第6期850-852,855,共4页Experimental and Laboratory Medicine

摘　　要：目的观察分析甲亢合并肺部感染患者血清抗炎与促炎介质的表达情况,为本类患者炎症介质的控制提供依据。方法选取2014年1月-2015年9月于本院进行诊治的64例甲亢合并肺部感染患者为A组,64例单纯甲亢患者为B组,64例单纯肺部感染患者为C组,64例健康人员为D组,然后将四组的血清抗炎介质与促炎介质表达水平进行比较,并比较A组和B组中不同基础代谢率、A组和C组中不同肺部感染严重程度者的血清表达水平。结果 A组的血清抗炎介质包括IL-10、TGF-β1与促炎介质包括IL-12、IL-18及TNF-α表达水平分别为(31.67±3.59)pg/ml、(66.76±8.24)ug/L及(135.45±12.67)pg/ml、(598.75±64.76)、pg/ml、(2.45±0.36)ng/ml,其均高于B组、C组及D组,B组及C组则高于D组,A组中基础代谢率的表达水平均高于B组,A组中不同肺部感染严重程度者的表达水平均高于C组,差异均有统计学意义(P<0.05),均有显著性。结论甲亢合并肺部感染患者血清抗炎与促炎介质呈现高表达状态,且感染及甲亢疾病状态均对其表达有较大的影响。Objective To study the expression situation of serum pro-inflammatory mediator and anti-inflammatory mediator of patients with hyperthyroidism complicated with pulmonary infection,in order to provide evidence for the control of inflammatory mediator.Methods A total of 64 patients with hyperthyroidism complicated with pulmonary infection in our hospital from January 2014 to September 2015 were selected as the group A,64 patients with only hyperthyroidism were selected as group B,64 patients with only pulmonary infection were selected as the group C,64 healthy persons were selected as the group D,then the expression levels of serum pro-inflammatory mediator and anti-inflammatory mediator of four groups were compared;the serum expression levels of group A and group B with different basal metabolic rates,group A and group C with different severity degree of pulmonary infection were also compared,respectively.Results The expression levels of serum anti-inflammatory mediator including IL-10,TGF-β1 and pro-inflammatory mediator including IL-12,IL-18,TNF-αof group A were 31.67±3.59pg/ml,66.76±8.24ug/L,135.45±12.67pg/ml,598.75±64.76pg/ml,and 2.45±0.36ng/ml,respectively.They all higher than those of group B,group C and group D.The levels of group B and group C were higher than those of group D,and the levels of group A with different basal metabolic rates were all higher than those of group B,the expression levels of group A with different severity degree of pulmonary infection were all higher than those of group C,with all P<0.05,the differences were all significant.Conclusion The serum pro-inflammatory mediator and anti-inflammatory mediator of patients with hyperthyroidism complicated with pulmonary infection show higher expression state,and ithe nfection and hyperthyroidism have great influence on the expression state.

关 键 词：甲亢 肺部感染 血清 抗炎介质 促炎介质 

分 类 号：R446.112[医药卫生—诊断学] R581.1[医药卫生—临床医学]