维生素E低相对分子质量肝素联合硫酸镁对早发型重度子痫前期患者核因子κB正五聚蛋白3水平及围生结局的影响  

Effects of vitamin E,low molecular weight heparin combined with magnesium sulfate on NF-kappa B,PTX3 and perinatal outcome in early onset severe preeclampsia

作　　者：刘伟[1] 赵丹[1] 刘倩[1] 安杰[1] 蔺静[1] 张倩[1] 李力[1] Liu Wei;Zhao Dan;Liu Qia;An Jie;Lin Jing;Zhang Qian;Li Li(Department of Obstetrics and Gynecology,East Hospital of Baoding First Central Hospital,Hebei 071000,China)

机构地区：[1]河北省保定市第一中心医院东院产科,071000

出　　处：《山西医药杂志》2018年第23期2797-2799,共3页Shanxi Medical Journal

摘　　要：目的探讨维生素E、低相对分子质量肝素联合硫酸镁对早发型重度子痫前期患者核因子κB(NF-κB)、正五聚蛋白3(PTX3)水平及围生结局的影响。方法选取我院2015—2017年收治的早发型重度子痫前期患者100例,随机将其分为对照组和观察组,每组50例。对照组给予硫酸镁常规治疗,观察组在对照组治疗的基础上给予维生素E和低相对分子质量肝素治疗,观察2组治疗前后NF-κB、PTX3水平、分娩结局及新生儿并发症的发生率。结果 2组患者的NF-κB、PTX3均有降低,且观察组患者降低程度明显高于对照组,差异有统计学意义(P<0.05)。2组产后出血、绒毛膜羊膜炎、宫内感染、产褥感染的发生率比较差异无统计学意义(P>0.05),但对照组产后并发症的总发生率明显高于观察组(χ2=6.31,P=0.012);2组胎儿窘迫、新生儿窒息、新生儿肺炎等并发症发生率比较差异无统计学意义(P>0.05),但对照组并发症总发生率明显高于观察组(χ2=10.21,P<0.05)。结论维生素E、低相对分子质量肝素联合硫酸镁能有效降低早发型重度子痫前期患者NF-κB、PTX3水平,并改善产妇及新生儿分娩结局。Objective To investigate the effects of vitamin E,low molecular weight heparin combined with magnesium sulfate on NF-kappa B,PTX3 and perinatal outcome in early onset severe preeclampsia.Methods A hundred cases of early onset severe preeclampsia patients from 2015 to 2017 in our hospital were randomly divided into control group and observation group,50 cases in each group.The control group was given magnesium sulfate routine treatment.The observation group was given vitamin E and low molecular weight heparin on the basis of the control group's treatment.The NF-kappa B and PTX3 levels,the delivery outcome and the incidence of neonatal complications before and after treatment of the two groups were observed.Results The NF-kappa B and PTX3 levels in both groups decreased,and the degree of decrease in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference in the incidence of postpartum chorioamnionitis,postpartum hemorrhage,intrauterine infection and puerperal infection between the two groups(P>0.05),but the total incidence of postpartum complications in the control group was significantly higher than that in the observation group(χ^2=6.31,P=0.012);There was no significant difference in the incidence of complications such as fetal distress,neonatal asphyxia and neonatal pneumonia between the two groups(P>0.05),but the incidence of complications in the control group was significantly higher than that in the observation group(χ^2=10.21,P<0.05).Conclusion Vitamin E,low molecular weight heparin combined with magnesium sulfate can effectively reduce the level of NF-kappa B and PTX3 in patients with early onset severe preeclampsia,and improve the delivery outcome of puerpera and newborns,which is worthy of clinical promotion.

关 键 词：子痫 维生素E 肝素 低分子量 分娩 NF-κB 正五聚蛋白3 

分 类 号：R714.244[医药卫生—妇产科学]