银翘散加减治疗急性感染性心内膜炎临床研究  

Clinical Observation of Yinqiao Decoction on Acute Infective Endocarditis

作　　者：雷程 杨颖[2] 张怡清[2] Lei Cheng;Yang Ying;Zhang Yiqing(Heilongjiang University of Traditional Chinese Medicine,Heilongjiang,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《中国中医急症》2018年第12期2129-2131,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：黑龙江省中医药科研项目(ZHY16-026)

摘　　要：目的观察银翘散加减治疗急性感染性心内膜炎(热毒侵心证)的临床效果。方法将70例急性感染性心内膜炎(热毒侵心证)患者随机分为对照组与观察组各35例,在抗菌、纠正心功能异常等常规治疗基础上,对照组给予左氧氟沙星治疗,观察组给予银翘散加减配合左氧氟沙星治疗。观察两组治疗2周后临床疗效及治疗前后中医证候积分、血清C反应蛋白与Osler结节消退情况。结果观察组治疗总有效率为97.14%,显著高于对照组的85.71%(P <0.05);治疗后两组中医证候积分及血清C反应蛋白、Osler结节消退情况均明显优于治疗前(均P <0.05)。结论银翘散加减治疗急性感染性心内膜炎(热毒侵心证)可以明显缓解患者中医证候,提高机体免疫能力,显著提高临床疗效。Objective:To investigate the clinical effect of Yinqiao Decoction on acute infective endocarditis.Methods:70patients with acute infective endocarditis were randomly divided into the control group and the observation group(n=35).On the basis of routine treatment,the control group was given levofloxacin,and the observation group was given Yinqiao Decoction.The clinical effects after2weeks,TCM syndrome scores before and after treatment,serum C-reactive protein and Osler nodule regression were observed.Results:The total effective rate of the observation group(97.14%)was significantly higher than that of the control group(85.71%)(P<0.05),and the scores of TCM syndromes,serum C-reactive protein and Osler nodule regression of both groups were significantly better than those before treatment(P<0.05).Conclusion:Yinqiao Decoction can obviously relieve the TCM syndromes of acute infective endocarditis,and improve the immune function and the clinical efficacy.

关 键 词：急性感染性心内膜炎 银翘散加减 中医证候 血清炎症因子 Osler结节消退 

分 类 号：R54[医药卫生—心血管疾病]