普罗布考预防经皮冠状动脉介入术后对比剂肾病效果评价  

Effect of Probucol on Contrast-Induced Nephropathy After PCI in Patients with Acute Myocardial Infarction

作　　者：黄郁玲[1] 廖宝霞[1] 连新龙[1] Huang Yuling;Liao Baoxia;Lian Xinlong(Department of Geratoloy,Qinghai Provincial People's Hospital’Xining,Qinghai’China)

机构地区：[1]青海省人民医院老年病科,青海西宁810007

出　　处：《中国药业》2018年第24期74-76,共3页China Pharmaceuticals

基　　金：青海省科技计划项目[2015-ZJ-752]

摘　　要：目的探讨普罗布考预防急性心肌梗死患者经皮冠状动脉介入术(PCI)术后对比剂肾病的效果。方法选取2017年1月至2018年1月行PCI手术治疗的急性心肌梗死患者232例,按随机数字表法分为对照组和观察组,各116例。两组患者均给予术前常规治疗,且术前12～24 h内静脉滴注0. 9%氯化钠注射液,观察组患者术前1 d至术后3 d内每日口服普罗布考片。结果术前1 d,两组患者血肌酐(SCr)、胱抑素C(Cys-C)、尿素氮(BUN)、β_2微球蛋白(β2-MG)、超敏C反应蛋白(hs-CRP)、中性粒细胞明胶酶相关脂质运载蛋白(NGAL)、内皮素-1(ET-1)、超氧化物歧化酶(SOD)、肾小球滤过率估算值(eGFR)和谷胱甘肽(GSH)水平比较,差异无统计学意义(P> 0. 05);术后3 d,两组患者上述指标除e GFR、ET-1水平降低外,其余指标水平均升高,且观察组均优于对照组(P <0. 05);术后3 d内,观察组对比剂肾病发生率为4. 31%,明显低于对照组的10. 34%(P <0. 05);两组患者住院期间均未发生肝功能异常、肌无力、心血管不良事件。结论普罗布考可缓解急性心肌梗死患者PCI术后的炎性反应和氧化应激反应,保护肾功能,降低对比剂肾病的发生率,值得临床推广。Objective To investigate the effect of probucol on contrast-induced nephropathy after percutaneous coronary intervention( PCI) in patients with acute myocardial infarction. Methods Totally 232 patients with acute myocardial infarction undergoing PCI in our hospital from January 2017 to January 2018 were selected and divided into the control group and the observation group according to the random number table method,116 cases in each group. The patients in the two groups were given routine preoperative routine therapy,and they were given intravenously drip of 0. 9% Sodium chloride Injection within 12-24 h before operation,and the patients in the observation group were given daily oral Probucol Tablets 1 d before aperation and within 3 d after operation. Results 1 d before operation,there was no significant difference in the levels of SCr,Cys-C,BUN,β2-MG,hs-CRP,NGAL,endothelin-1( ET-1),SOD,e GFR and GSH between the two groups( P > 0. 05). 3 d after operation,the above indexes of the two groups were increased except for the decrease of e GFR and ET-1 levels,and those in the observation group were better than those in the control group( P < 0. 05). Within 3 d after operation,the incidence rate of contrast-induced nephropathy in the observation group was 4. 31%,which was significantly lower than 10. 34% in the control group( P < 0. 05). There were no abnormal liver function,myasthenia and cardiovascular events in both groups during hospitalization. Conclusion Probucol can alleviate inflammatory reaction and oxidative stress after PCI in patients with acute myocardial infarction,it also can protect renal function and reduce the incidence rate of contrast-induced nephropathy,which is worthy of clinical promotion.

关 键 词：普罗布考 急性心肌梗死 经皮冠状动脉介入术 对比剂肾病 肾功能 临床疗效 

分 类 号：R969.4[医药卫生—药理学] R972.6[医药卫生—药学]