急性冠脉综合征患者血清骨髓相关蛋白水平、外周血单个核细胞Toll样受体4表达情况及其相关性研究  

Serum MRP Level and PBMC TLR4 Ratio in Patients with Acute Coronary Syndrome and Their Correlation

作　　者：刘贵京[1] 施海法[2] 张素华[2] 王晓利 范晓飞[1] 康美玉[3] 呼金田[4] 燕霞[5] LIU Gui-jing;SHI Hai-fa;ZHANG Su-hua;WANG Xiao-li;FAN Xiao-fei;KANG Mei-yu;HU Jin-tian;YAN Xia(Department of Cardiology,the Affiliated Hospital of Hebei University of Engineering,Handan 056000,China;Department of Emergency,the Affiliated Hospital of Hebei University of Engineering,Handan 056000,China;Medical College of Hebei University of Engineering,Handan 056000,China;Department of Laboratory Medicine,the Affiliated Hospital of Hebei University of Engineering,Handan 056000,China;Department of Medical Matters,the Affiliated Hospital of Hebei University of Engineering,Handan 056000,China)

机构地区：[1]河北工程大学附属医院心内科,河北省邯郸市056000 [2]河北工程大学附属医院急诊科,河北省邯郸市056000 [3]河北工程大学医学院,河北省邯郸市056000 [4]河北工程大学附属医院检验科,河北省邯郸市056000 [5]河北工程大学附属医院医务处,河北省邯郸市056000

出　　处：《实用心脑肺血管病杂志》2018年第10期24-27,共4页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：政府资助省级临床医学优秀人才项目(361037)

摘　　要：目的探讨急性冠脉综合征(ACS)患者血清骨髓相关蛋白(MRP)水平、外周血单个核细胞Toll样受体4(TLR4)表达情况,并分析二者的相关性。方法选取2015年3月—2016年3月河北工程大学附属医院心内科收治的ACS患者50例,其中急性心肌梗死(AMI)25例(AMI组)、不稳定型心绞痛(UAP)25例(UAP组);另选取同期稳定型心绞痛(SAP)患者20例作为SAP组,体检健康者24例作为对照组。比较4组受试者血压、血糖相关指标、血脂指标、血清MRP水平及外周血单个核细胞TLR4阳性率,ACS患者血清MRP水平与外周血单个核细胞TLR4阳性率的相关性分析采用Pearson相关分析。结果 (1)4组受试者舒张压、空腹血糖、糖化血红蛋白(HbA1c)、高密度脂蛋白(HDL)及低密度脂蛋白(LDL)比较,差异无统计学意义(P>0.05);UAP组和AMI组患者收缩压、TG高于对照组和SAP组(P<0.05)。(2)UAP组和AMI组患者血清MRP水平和外周血单个核细胞TLR4阳性率高于对照组和SAP组(P<0.05);对照组与SAP组、UAP组与AMI组受试者血清MRP水平和外周血单个核细胞TLR4阳性率比较,差异均无统计学意义(P>0.05)。(3)Pearson相关分析结果显示,血清MRP水平与ACS患者外周血单个核细胞TLR4阳性率呈正相关(r=0.796,P<0.01)。结论 ACS患者血清MRP水平及外周血单个核细胞TLR4表达升高,且二者呈正相关,推测MRP可能通过激活TLR4而参与ACS的发生、发展。Objective To investigate the serum MRP level and PBMC TLR4ratio in patients with acute coronary syndrome and their correlation.Methods From March2015to March2016,a total of50patients with acute coronary syndrome were selected in the Department of Cardiology,the Affiliated Hospital of Hebei University of Engineering,thereinto25cases with acute myocardial infarction were served as AMI group,the other25cases with unstable angina pectoris were served as UAP group;meanwhile a total of20patients with stable angina pectoris were selected as SAP group,a total of24healthy volunteers were selected as control group.Blood pressure,blood glucose related index,blood lipid index,serum MRP level and PBMC TLR4positive rate were compared in the four groups,and Pearson correlation analysis was used to analyze the correlation between serum MRP level and PBMC TLR4positive rate in patients with acute coronary syndrome.Results(1)No statistically significant differences of DBP,FGP,HbA1c,HDL or LDL was found in the four groups(P>0.05),while SBP and TG in UAP group and AMI group were statistically significantly higher than those in control group and SAP group(P<0.05).(2)Serum MRP level and PBMC TLR4positive ratio in UAP group and AMI group were statistically significantly higher than those in control group and SAP group(P<0.05),while no statistically significant differences of serum MRP level or PBMC TLR4positive rate was found between control group and SAP group,between UAP group and AMI group(P>0.05).(3)Pearson correlation analysis results showed that,serum MRP level was positively correlated with PBMC TLR4positive rate in patients with acute coronary syndrome(r=0.796,P<0.01).Conclusion Serum MRP level and PBMC TLR4positive rate are elevated in patients with acute coronary syndrome,and they are positively correlated,MRP may play a role in the occurrence development of acute coronary syndrome through activating TLR4.

关 键 词：急性冠脉综合征 骨髓相关蛋白 TOLL 样受体4 

分 类 号：R542.2[医药卫生—心血管疾病]