血清脑源性神经营养因子水平与原发性高血压患者抑郁症的关系研究  

Relationship between Serum BDNF Level and Depression in Patients with Essential Hypertension

作　　者：覃咏梅 林玲[2] 王延博 王蓓[2] 周莲[3] QIN Yong-mei;LIN Ling;WANG Yan-bo;WANG Bei;ZHOU Lian(Graduate School of Guangzhou Medical University,Guangzhou 511400,China;Department of Cardiovascular Medicine,the Third People's Hospital of Hainan Province,Sanya 572000,China;Department of Laboratory Medicine,the Third People's Hospital of Hainan Province,Sanya 572000,China)

机构地区：[1]广州医科大学研究生院,广东省广州市511400 [2]海南省第三人民医院心血管内科,海南省三亚市572000 [3]海南省第三人民医院检验科,海南省三亚市572000

出　　处：《实用心脑肺血管病杂志》2018年第10期28-31,36,共5页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：海南省自然科学基金面上项目(20168343)

摘　　要：目的探讨血清脑源性神经营养因子(BDNF)水平与原发性高血压患者抑郁症的关系。方法选取2017年4—12月海南省第三人民医院心血管内科门诊和住院部收治的原发性高血压患者150例,根据有无抑郁症分为无抑郁症组90例和抑郁症组60例;抑郁症组患者中轻度抑郁症32例,中重度抑郁症28例(其中重度抑郁症5例)。比较两组患者临床特征、空腹血糖(FBP)、血脂指标及血清BDNF水平,原发性高血压患者抑郁症的影响因素分析采用多因素Logistic回归分析;比较不同抑郁症严重程度患者血清BDNF水平,血清BDNF水平与原发性高血压并抑郁症患者抑郁自评量表(SDS)评分的相关性分析采用Pearson相关分析。结果 (1)两组患者性别、年龄、体质指数(BMI)、收缩压(SBP)及舒张压(DBP)比较,差异无统计学意义(P>0.05);抑郁症组患者高血压病程长于无抑郁症组,高血压分级劣于无抑郁症组(P<0.05)。(2)两组患者FBP及血清三酰甘油(TG)水平比较,差异无统计学意义(P>0.05);抑郁症组患者血清总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、BDNF水平低于无抑郁症组,血清高密度脂蛋白胆固醇(HDL-C)水平高于无抑郁症组(P<0.05)。(3)多因素Logistic回归分析结果显示,血清BDNF水平是原发性高血压患者抑郁症的保护因素[OR=0.999,95%CI(0.999,1.000),P<0.001]。(4)中重度抑郁症患者血清BDNF水平低于轻度抑郁症患者(P<0.001);进一步行Pearson相关分析结果显示,血清BDNF水平与原发性高血压并抑郁症患者SDS评分呈负相关(r=-0.510,P<0.001)。结论血清BDNF水平是原发性高血压患者抑郁症的保护因素,血清BDNF水平越低则患者抑郁症程度越重,BDNF可能参与原发性高血压患者抑郁症的发生发展。Objective To investigate the relationship between serum BDNF level and depression in patients with essential hypertension.Methods From April to December2017,a total of150outpatients and inpatients with essential hypertension were selected in the Department of Cardiovascular Medicine,the Third People's Hospital of Hainan Province,and they were divided into non-depression group(n=90)and depression group(n=60)according to the incidence of depression;in depression group,there were32cases with mild depression,28cases with moderate or severe depression(including5cases with severe depression).Clinical features,FBP,blood lipid index and serum BDNF level were compared between the two groups,multivariate Logistic regression analysis was used to analyze the influencing factors of depression in patients with essential hypertension;serum BDNF level was compared in patients with severity of depression,and Pearson correlation analysis was used to analyze the correlation between serum BDNF level and SDS score in essential hypertension patients accompanied with depression.Results(1)No statistically significant differences of gender,age,BMI,SBP or DBP was found between the two groups(P>0.05);hypertension course in depression group was statistically significantly longer than that in nondepression group,and hypertension grading in depression group was statistically ignificantly worse than that in non-depression group(P<0.05)(.2)No statistically significant differences of FBP or serum TG level was found between the two group(s P>0.05);serum levels of TC,LDL-C and BDNF in depression group were statistically significantly lower than those in non-depression group,while serum HDL-C level in depression group was statistically significantly higher than that in non-depression group(P<0.05).(3)Multivariate Logistic regression analysis results showed that,serum BDNF level was the protective factor of depression in patients with essential hypertension〔OR=0.999,95%CI(0.999,1.000),P<0.001〕.(4)Serum BDNF level in patients with moderate or sev

关 键 词：原发性高血压 抑郁症 脑源性神经营养因子 影响因素 

分 类 号：R544.1[医药卫生—心血管疾病]